To compare and evaluate the antimicrobial efficacy (in terms of bacterial load reduction) of combination of ozone oil with Chitosan Nano-particle and Double Antibiotic Paste as intracanal medicament in teeth requiring retreatment of previously done root canal therapy.
- Conditions
- Diseases of pulp and periapical tissues, (2) ICD-10 Condition: K045||Chronic apical periodontitis, (3) ICD-10 Condition: K045||Chronic apical periodontitis, (4) ICD-10 Condition: K045||Chronic apical periodontitis, (5) ICD-10 Condition: K045||Chronic apical periodontitis,
- Registration Number
- CTRI/2023/02/049482
- Lead Sponsor
- Dr Harshit Mavani
- Brief Summary
Innovative approaches are necessary to prevent and eradicate biofilmformation. Antimicrobial, antibiofilm and anti-virulent efficacy of ChitosanNano-Particle Nano-particles and O3-oil against the S. mutans, E. faecalis, andC. albicans bacterial-fungal biofilm that is encountered in many resistantendodontic infections can be tested to prove their efficacy in doing so. Little is known about *in vivo* efficacy of ozonated oil with ChitosanNano-Particle nanoparticles against microbial species isolated from persistentendodontic infections. The present study is aimed to evaluate the antibacterialeffect of combination of Chitosan Nano-Particle Nanoparticles with ozonated oil-used as an intracanal medicament in endodontic retreatment, as there were no studiessearched on PubMed, Cochrane, Google Scholar and Science Direct.
Therefore, theaim of this study is to evaluate and compare antibacterial efficacy ofcombination of Chitosan Nano-Particle with ozonated oil and Double AntibioticPaste in Endodontic retreatment using bacterial colony forming units.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 32
- Systemically healthy patients, i.e., Class I patients according to American Society of Anaesthesiology [ASA] classification having multirooted teeth diagnosed with post treatment apical periodontitis will be included.
- Teeth indicated for endodontic retreatment will be included.
- A written informed consent will be taken from all the patients and only those patients ready to sign the consent form will be included in the study.
- Patients who received antibiotic therapy within the previous 3 months Teeth with vertical root fracture Teeth with periodontal pockets deeper than 4 mm Teeth in which prosthesis could not be removed.
- Teeth with severe crown destruction Teeth with separated instrument Patients with known allergy to Shrimps/Chitosan.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The result of this study will help us to know about the antibacterial efficacy of combination of ozone oil with chitosan nanoparticle as intracanal medicament First sample will be taken at baseline. Second sample will be taken after a week (7 days)
- Secondary Outcome Measures
Name Time Method To know which has better antibacterial activity between combination of ozone oil with chitosan nanoparticle and double antibiotic paste 7 days
Trial Locations
- Locations (1)
K.M Shah Dental College and Hospital
🇮🇳Vadodara, GUJARAT, India
K.M Shah Dental College and Hospital🇮🇳Vadodara, GUJARAT, IndiaDr Harshit MavaniPrincipal investigator8460242073harshitmavani@gmail.com