Effects of multimodal rehabilitation on recovery of ICU Acquired weakness following COVID-19

Not Applicable

Conditions: Condition 1: Novel Coronavirus(COVID-19). Condition 2: Intensive Care Unit Acquired Weakness.
Clinically-epidemiologically diagnosed COVID-19
Critical illness myopathy
U07.1
G72.81

Registration Number: IRCT20200117046160N2

Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 27

Inclusion Criteria

Definitive diagnosis of Coronavirus based on Polymerase Chain Reaction (PCR) or lung CT Scan and expert opinion
Intensive Care Unit Acquired Weakness (ICUAW) diagnosis based on the following criteria: - Total muscle strength points of 6 muscle groups bilaterally (Forearm flexion, wrist extension, Hip flexion, knee extension, Ankle dorsiflexion, Arm abduction) in manual examination according to Medical Research Council(MRC) criteria is less than 48 (out of 60 total points) - Normal consciousness based on Glasgow Coma Scale(GCS) (score 15 out of 15) - Opinion of an Anesthesiologist or Intensive Care Fellowship - History of hospitalization in ICU for more than 48 hours (with and without the need for Mechanical ventilation)

Exclusion Criteria

Loss of consciousness
Uncontrolled hypertension means: resting systolic blood pressure> 180 mmHg and / or resting diastolic blood pressure> 110 mmHg
Chest pain
Uncontrolled sinus tachycardia (> 120 beats / min) or Sinus bradycardia (HR <60)
Concurrent heart disease such as: Decompensated heart failure and evidence of Ischemic heart disease, Symptomatic arrhythmia
Hypoxia at rest (Oxygen saturation (SPO2)< 88%)
Pulmonary artery hypertension (Pulmonary Artery Pressure(PAP) > 30mmHg)
Fever or Acute systemic disease
Uncontrolled Diabetes Mellitus( DM)
Severe Orthopedic or Neurological problems that prevent exercise
Other metabolic conditions such as: Acute thyroiditis, Hyperkalemia, Hypokalemia and Hypovolemia (Until adequate treatment)
Severe Psychological disorders
Poor compliance
Problem transporting the patient to the Rehabilitation Center
Absence of the patient from rehabilitation sessions (More than 2 sessions)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of life. Timepoint: Before the intervention and after the intervention (after 16th session). Method of measurement: World Health Organization Questionnaire.;Peripheral muscle force. Timepoint: Before the intervention and after the intervention (after 16th session). Method of measurement: Medical Research Council grading system.

Secondary Outcome Measures