Entyvio (Vedolizumab) Long Term Safety Study

Completed

• Conditions: Ulcerative Colitis and Crohn's Disease
• Interventions: Other: Other Biologic Agents; Drug: Vedolizumab

• Registration Number: NCT02674308
• Lead Sponsor: Takeda

Brief Summary

The purpose of this study is to assess the long-term safety of vedolizumab versus other biologic agents in participants with Ulcerative Colitis (UC) or Crohn's Disease (CD).

Detailed Description

The drug being tested in this prospective, observational study is called vedolizumab. Vedolizumab is being used to treat people who have UC or CD. This study will look at the long-term safety of vedolizumab versus other biologic agents in participants with UC or CD. The study will enroll approximately 5000 participants. All participants enrolled in this will belong to one of the two treatment group:

* Vedolizumab

* Other Biologic Agents -adalimumab, certolizumab pegol.

Golimumab and infliximab. Study drugs will be prescribed by the physician according to local prescribing information in the participating countries. This multi-centre trial will be conducted worldwide. The overall time to participate in this study is 7 years. Participants will make visits at every 6 months to their treating physician.

Study Timeline

• Study Start: 2015-03-24
• Study First Submitted: 2016-01-29
• Study First Submitted QC: 2016-02-02
• Study First Posted: 2016-02-04
• Primary Completion: 2021-07-30
• Study Completion: 2021-07-30
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-30
• Last Update Posted: 2024-10-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5302

Inclusion Criteria

1. Signed informed consent, by the participant or a legally acceptable representative.
2. Aged at least 18 years.
3. Initiating vedolizumab or another biologic agent for UC or CD.
4. Signed release form, by the participant or a legally acceptable representative, permitting abstraction of the participant's medical records at Baseline and during participation in the study.

Exclusion Criteria

1. The participant is enrolled in a clinical trial in which treatment for CD or UC is managed through a protocol.
2. Prior treatment with vedolizumab.
3. Any other reason that, in the Investigator's opinion, makes the participant unsuitable to participate in this study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Other Biologic Agents	Other Biologic Agents	-
Vedolizumab	Vedolizumab	-

Primary Outcome Measures

Name	Time	Method
Percentage of Participants with Adverse Events of Special Interest	7 years	Adverse events of special interest in this study includes serious and opportunistic infections, gastrointestinal infections, respiratory infections, other clinically significant infections: malignancies; infusion-related reactions and hypersensitivity, hepatic injury; psoriasis and other skin events, other SAEs and adverse reactions.

Secondary Outcome Measures

Name	Time	Method
Disease Severity in Ulcerative Colitis (UC) Participants	Baseline and at every 6 months (up to 7 years)	Disease severity will be measured using the Mayo score for ulcerative colitis and is ranged from 0 (normal or inactive disease) to 9 (severe disease) and calculated as the sum of 3 subscores: stool frequency, rectal bleeding and physician rating of disease activity, each ranged from 0 to 3 (0=normal, 1=mild, 2=moderate, 3=severe).
Disease Severity in Crohn's Disease (CD) Participants	Baseline and at every 6 months (up to 7 years)	Disease severity will be measured using the Harvey-Bradshaw Index (HBI) for crohn's disease. HBI is used in the assessment and quantification of symptoms and the present level of disease activity of participants with Crohn's disease. It is a validated clinical index for Crohn's disease,HBI score consists of clinical parameters of general well-being (0= very well 1=slightly below average, 2=poor, 3=very poor, 4=terrible); abdominal pain (0=none, 1=mild, 2=moderate, 3=severe); number of liquid stools per day; abdominal mass (0=none, 1=dubious, 2=definite, 3=tender); and complications (8 items: arthralgia, uveitis, erythema nodosum, aphthous ulcers, pyoderma gangrenosum, anal fissures, new fistula, abscess \[score 1 per item\]).Lower scores indicate better well-being. The scores are classified as: \<5=remission, 5-7=mild disease, 8-16=moderate disease and \>16=severe disease. Minimum score is 0 and no pre-specified maximum score as it depends on the number of liquid stools.
Participant Reported Quality of Life Assessment Using Short Inflammatory Bowel Disease Questionnaire (SIBDQ)	Baseline and at every 6 months (up to 7 years)	The Short IBD Questionnaire is an instrument used to assess quality of life and is a disease-specific health-related quality of life questionnaire, that consists of 10 questions, each question is scored on a scale from 1 (poor quality of life) to 7 (good quality of life). The scores are summed up and divided by 10 for a mean score ranging from 1 (poor quality of life) to 7 (good quality of life). A higher score indicates a better health-related quality of life.
Participant Reported Quality of Life Assessment Using 12-Item Short Form Health Survey (SF-12)	Baseline and at every 6 months (up to 7 years)	The SF-12 health questionnaire is a 12 question assessment of functional health and well-being. The survey asks about various health aspects, including physical functioning, role limitations due to physical health problems, bodily pain, general health, vitality, social functioning, role limitations due to emotional problems, and mental health (psychological distress and psychological well-being). Two summary measures are derived: the Physical and the Mental Health Component Summary. For each component summary, survey items were weighted and summed to create a summary score between 0 and 100 with higher score indicating better quality of life.
Time to Treatment Discontinuation	Baseline and at every 6 months (up to 7 years)	Time to discontinuation for Entyvio and the other biologic agents will be measured.
Reasons for Treatment Discontinuation	Baseline and at every 6 months (up to 7 years)	Reasons for discontinuations for Entyvio and the other biologic agents will be measured.

Trial Locations

Locations (284)

University of Alabama; 🇺🇸 Birmingham, Alabama, United States

University of South Alabama; 🇺🇸 Mobile, Alabama, United States

University of Arizona Medical Center; 🇺🇸 Tucson, Arizona, United States

Scripps Clinic; 🇺🇸 La Jolla, California, United States

Stanford University; 🇺🇸 Palo Alto, California, United States

South Bay Gastroenterology Medical Group; 🇺🇸 Torrance, California, United States

Gastroenterology Center of Connecticut P.C.; 🇺🇸 Hamden, Connecticut, United States

Middlesex Gastroenterology Associates, Llc; 🇺🇸 Middletown, Connecticut, United States

Gastroenterology Group of Naples; 🇺🇸 Naples, Florida, United States

Florida Hospital Orlando; 🇺🇸 Orlando, Florida, United States

Gulf Region Clinical Research Institute; 🇺🇸 Pensacola, Florida, United States

Emory University Hospital, the Emory Clinic; 🇺🇸 Atlanta, Georgia, United States

Atlanta Gastroenterology Associates; 🇺🇸 Suwanee, Georgia, United States

Georgia Regents University; 🇺🇸 Augusta, Georgia, United States

Illinois Gastroenterology Groupllc Northwest Gastroenterologists; 🇺🇸 Arlington Heights, Illinois, United States

Rush University Medical Center; 🇺🇸 Chicago, Illinois, United States

University of Chicago Medical Center; 🇺🇸 Chicago, Illinois, United States

Northshore University Health Systems; 🇺🇸 Evanston, Illinois, United States

Loyola University; 🇺🇸 Maywood, Illinois, United States

Southwest Gastroenterology; 🇺🇸 Oak Lawn, Illinois, United States

University of Iowa Hospitals and Clinics; 🇺🇸 Iowa City, Iowa, United States

The University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States

Cotton O'Neil Digestive Health Center; 🇺🇸 Topeka, Kansas, United States

Kansas Gastroenterology; 🇺🇸 Wichita, Kansas, United States

University of Louisville; 🇺🇸 Louisville, Kentucky, United States

New Orleans Research Institute; 🇺🇸 Metairie, Louisiana, United States

Louisiana Research Center, Llc; 🇺🇸 Shreveport, Louisiana, United States

Crohn'S and Colitis Center; 🇺🇸 Boston, Massachusetts, United States

Boston University Moakley Building Center For Digestive Disorders; 🇺🇸 Boston, Massachusetts, United States

Umass Memorial Medical Center; 🇺🇸 Worcester, Massachusetts, United States

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States

Infusion Associates, Grand Rapids; 🇺🇸 Grand Rapids, Michigan, United States

Mayo Clinic - Rochester; 🇺🇸 Rochester, Minnesota, United States

Digestive Health Center, Pa; 🇺🇸 Ocean Spring, Mississippi, United States

St. Louis University; 🇺🇸 Saint Louis, Missouri, United States

Washington University; 🇺🇸 Saint Louis, Missouri, United States

Chi Health Alegent Creighton Clinic; 🇺🇸 Omaha, Nebraska, United States

Dartmouth-Hitchcock Medical Center; 🇺🇸 Lebanon, New Hampshire, United States

Englewood Endoscopic Associates; 🇺🇸 Englewood, New Jersey, United States

Morristown Medical Center; 🇺🇸 Morristown, New Jersey, United States

Saratoga-Schenectady Gastroenterology Associates; 🇺🇸 Burnt Hills, New York, United States

Digestive Disease Center; 🇺🇸 Fishkill, New York, United States

Northwell Health; 🇺🇸 Great Neck, New York, United States

Nyu Langone Long Island Clinical Research Associates; 🇺🇸 Great Neck, New York, United States

Nyu Langone Medical Center; 🇺🇸 New York, New York, United States

Icahn School of Medicine At Mount Sinai; 🇺🇸 New York, New York, United States

Lenox Hill Hospital; 🇺🇸 New York, New York, United States

Gastroenterology Group of Rochester; 🇺🇸 Rochester, New York, United States

University of North Carolina; 🇺🇸 Chapel Hill, North Carolina, United States

Carolina Research; 🇺🇸 Greenville, North Carolina, United States

Wake Research Associates; 🇺🇸 Raleigh, North Carolina, United States

Wake Forest University School of Medicine; 🇺🇸 Winston-Salem, North Carolina, United States

Trihealth Digestive Institute; 🇺🇸 Cincinnati, Ohio, United States

Mark Osterman; 🇺🇸 Philadelphia, Pennsylvania, United States

Philadelphia Va Medical Center; 🇺🇸 Philadelphia, Pennsylvania, United States

Medical University of South Carolina; 🇺🇸 Charleston, South Carolina, United States

Consultants in Gastroenterology - Columbia; 🇺🇸 Columbia, South Carolina, United States

Vanderbilt University Medical Center; 🇺🇸 Nashville, Tennessee, United States

Baylor University Medical Center; 🇺🇸 Houston, Texas, United States

Ut Health Science Center; 🇺🇸 Houston, Texas, United States

Spring Gastroenterology; 🇺🇸 Humble, Texas, United States

University of Virginia Health System; 🇺🇸 Charlottesville, Virginia, United States

Virginia Mason Medical Center; 🇺🇸 Seattle, Washington, United States

Medical College of Wisconsin; 🇺🇸 Milwaukee, Wisconsin, United States

Krankenhaus Der Elisabethinen Linz Gmbh; 🇦🇹 Oberosterreich, Austria

Kh Der Barmherzigen Schwestern; 🇦🇹 Ried Im Innkreis, Austria

Ordination Dr. Thomas Haas Darmpraxis Salzburg; 🇦🇹 Salzburg, Austria

Salk Salzburg; 🇦🇹 Salzburg, Austria

Landesklinikum St. Poelten; 🇦🇹 St. Poelten, Austria

KH WELS; 🇦🇹 Wels, Austria

Medizinischen Universitat Wien - Allgemeines Krankenhaus (Akh) - Universitaetsklinik Fuer Innere Medizin Iii; 🇦🇹 Wien, Austria

Loha For Life; 🇦🇹 Wien, Austria

Olv Aalst - Gastro-Enterologie; 🇧🇪 Aalst, Belgium

Imelda - Gastro-Enterologie; 🇧🇪 Bonheiden, Belgium

Chu Saint Pierre - Service de Gastroenterologie; 🇧🇪 Brussels, Belgium

Cub Hopital Erasme; 🇧🇪 Brussels, Belgium

Uz Brussel - Gastro-Enterologie; 🇧🇪 Brussels, Belgium

HIS-IZZ; 🇧🇪 Bruxelles, Belgium

Uz Antwerpen - Gastro-Enterologie; 🇧🇪 Edegem, Belgium

Ziekenhuis Oost Limburg - Gastro-Enterologie; 🇧🇪 Genk, Belgium

Az Maria Middelares - Gastro-Enterologie; 🇧🇪 Gent, Belgium

Az St Lucas - Gastro-Enterologie; 🇧🇪 Gent, Belgium

Uz Gent - Gastro-Enterologie; 🇧🇪 Gent, Belgium

Jessa Ziekenhus - Gastro-Enterologie; 🇧🇪 Hasselt, Belgium

Az Groeninge - Campus Kennedylaan - Gastro-Enterologie; 🇧🇪 Kortrijk, Belgium

Universitaire Ziekenhuizen (Uz) Leuven - Gasthuisberg; 🇧🇪 Leuven, Belgium

Centre Hospitalier Chretien (Chc) - Clinique Saint-Joseph (Hopital St-Joseph) - Gastro-Enterologie; 🇧🇪 Liege, Belgium

Chr de La Citadelle; 🇧🇪 Liege, Belgium

Chu Liege - Gastro-Enterologie; 🇧🇪 Liege, Belgium

Az Sint Maarten, Campus Rooienberg; 🇧🇪 Mechelen, Belgium

Chu Ambroise-Pare; 🇧🇪 Mons, Belgium

Clinique Et Maternite Sainte-Elisabeth; 🇧🇪 Namur, Belgium

Clinique St Pierre Asbl; 🇧🇪 Ottignies, Belgium

Az Delta - Gastro-Enterologie; 🇧🇪 Roeselare, Belgium

Centre Hospitalier de Wallonie Picardie, Site Notre Dame; 🇧🇪 Tournai, Belgium

Okanagan Clinical Trials Ltd.; 🇨🇦 Kelowna, British Columbia, Canada

Nova Scotia Health Authority; 🇨🇦 Halifax, Nova Scotia, Canada

McMasters University; 🇨🇦 Hamilton, Ontario, Canada

Scott Shulman Medical Prof. Corp; 🇨🇦 North Bay, Ontario, Canada

Taunton Surgical Centre-Oshawa Clinic; 🇨🇦 Oshawa, Ontario, Canada

University of Toronto - St. Michaels Hospital; 🇨🇦 Toronto, Ontario, Canada

Royal University Hospital; 🇨🇦 Saskatoon, Saskatchewan, Canada

University Hospital Center Osijek; 🇭🇷 Osijek, Croatia

Clinical Hospital Centre Split; 🇭🇷 Split, Croatia

Kbc Split; 🇭🇷 Split, Croatia

University Hospital Dubrava; 🇭🇷 Zagreb, Croatia

University Hospital, Aalborg; 🇩🇰 Aalborg, Denmark

Bispebjerg Univarsity Hospital; 🇩🇰 Copenhagen Nv, Denmark

Rigshospitalet, Abdominal Centre; 🇩🇰 Copenhagen, Denmark

Hvidovre Hospital; 🇩🇰 Hvidovre, Denmark

Nykobing Falster Sygehus; 🇩🇰 Nykobing Falster, Denmark

Silkeborg Hospital; 🇩🇰 Silkeborg, Denmark

West-Tallinn Central Hospital (Ltkh); 🇪🇪 Tallinn, Estonia

North Estonian Regional Hospital; 🇪🇪 Tallinn, Estonia

Tartu University Hospital; 🇪🇪 Tartu, Estonia

Chu Amiens Picardie - Service Hepato-Gastro-Enterologie; 🇫🇷 Amiens, France

C H U Angers; 🇫🇷 Angers, France

Hopital Avicenne; 🇫🇷 Bobigny, France

Centre Hospitalier Universitaire (Chu) de Caen - Service D'Hepatogastroenterologie; 🇫🇷 Caen Cedex, France

C.H.U de Tours - Hopital Trousseau; 🇫🇷 Chambray-les-tours, France

Chu de Clermont Ferrand - Hopital Estaing; 🇫🇷 Clermont Ferrand, France

Hopitaux Civils de Colmar; 🇫🇷 Colmar Cedex, France

Centre Hospitalier Regional Universitaire (Chru) de Lille - Hopital Claude Huriez; 🇫🇷 Lille, France

Hospices Civils de Lyon (Hcl) - Hopital Edouard Herriot; 🇫🇷 Lyon, France

Chu Hopital Nord, Marseille - Service D'Hepato-Gastro-Enterologie; 🇫🇷 Marseille, France

University Hospital St Eloi; 🇫🇷 Montpellier, France

Centre Hospitalier Universitaire (Chu) de Nice - Hopital L'Archet 2 - Pole Digestif; 🇫🇷 Nice, France

Chu Nimes - Hopital Caremeau; 🇫🇷 Nimes, France

Institut Mutualiste Montsouris; 🇫🇷 Paris Cedex 14, France

Centre Hospitalo Universitaire (Chu) - Hopital Saint-Antoine; 🇫🇷 Paris, France

Hopital Du Haut Leveque - Service D'Hepato-Gastro-Enterologie Et Nutritution, Unite de Soin Normalise; 🇫🇷 Pessac Cedex, France

Hospices Civils de Lyon (Hcl) - Centre Hospitalier Lyon-Sud - Hepatogastroenterologie; 🇫🇷 Pierre Benite, France

Centre Hospitalier Annecy Genevois; 🇫🇷 Pringy, France

Chu de Reims - Hopital Robert Debre; 🇫🇷 Reims, France

Centre Hospitalier Universitaire (Chu) de Rouen; 🇫🇷 Rouen, France

Service Gastro-Enterologie Hopital Nord - Chu de Saint Etienne; 🇫🇷 Saint-etienne, France

Hopital Rangueil - Service de Gastroenterologie; 🇫🇷 Toulouse Cedex 9, France

Ch Gustave Dron - Hopital de Tourcoing; 🇫🇷 Tourcoing Cedex, France

Ch Valenciennes - Hopital Jean Bernard - Service Maladies de L'Appareil Digestif Et de La Nutrition; 🇫🇷 Valenciennes, France

Praxis Dr. Med. Eberhard Meier; 🇩🇪 Amberg, Germany

Charite Campus Campus Mitte; 🇩🇪 Berlin, Germany

Praxis Dr. Mross; 🇩🇪 Berlin, Germany

Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin (Cbf) - Medizinische Klinik I; 🇩🇪 Berlin, Germany

Charite Campus Virchow Klinikum - Medizinische Klinik Mit Schwerpunkt Hepatologie Und Gastroenterologie; 🇩🇪 Berlin, Germany

Praxis Fur Gastroenterologie Am Bayerischen Platz; 🇩🇪 Berlin, Germany

Sana Klinik Biberach; 🇩🇪 Biberach, Germany

Medizinisches Versorgungszentrum (Mvz) Dachau; 🇩🇪 Dachau, Germany

Stadtisches Klinikum Dessau; 🇩🇪 DESSAU-ROsLAU, Germany

Technische Universitaet Dresden - Universitaetklinikum Carl Gustav Carus - Medizinische Klinik Und Poliklinik I; 🇩🇪 Dresden, Germany

Universitatsklinikum Erlangen Medizinische Klinik I - Studien Ambulanz Ced; 🇩🇪 Erlangen, Germany

St. Josef Krankenhaus Essen-Werden / Abteilung Fur Gastroenterologie; 🇩🇪 Essen, Germany

Crohn-Colitis Centrum Rhein-Main; 🇩🇪 Frankfurt Am Main, Germany

Agaplesion Markus Krankenhaus, Medizinische Klinik 1; 🇩🇪 Frankfurt, Germany

Praxis Dr. Med. Thomas Zeisler; 🇩🇪 Halle (saale), Germany

Krankenhaus Martha-Maria Halle Dolau Ggmbii, Klinik Fur Innere Medizin I; 🇩🇪 Halle, Germany

Universitatsklinik Und Poliklinik Fur Innere Medizin I; 🇩🇪 Halle, Germany

Hafced E.K.; 🇩🇪 Hamburg Eppendorf, Germany

Asklepios Westklinikum Hamburg; 🇩🇪 Hamburg, Germany

Universitatsklinikum Heidelberg; 🇩🇪 Heidelberg, Germany

Praxis Fur Gastroenterologie; 🇩🇪 Heidelberg, Germany

Gastroenterologische Gemeinschaftspraxis Dr. Felten; 🇩🇪 Herne, Germany

Praxis Group; 🇩🇪 Nurnberg, Germany

PRAXIS; 🇩🇪 Kothen, Germany

Eugastro Gmbh; 🇩🇪 Leipzig, Germany

Universitat Leipzig, Medizinische Fakultat; 🇩🇪 Leipzig, Germany

Gesellschaft Fuer Klinische Studien; 🇩🇪 Leipzig, Germany

St. Marien Krankenhauses - Medizinischen Klinik I; 🇩🇪 Ludwigshafen Am Rhein, Germany

Staedtisches Klinikum Luneburg; 🇩🇪 Luneburg, Germany

Universitatsklinikum Magdeburg A. O. R. - Klinik Fur Gastroenterologie; 🇩🇪 Magdeburg, Germany

Universitaetsmedizin Mainz, I.Med.Klinik, Geb.605, Eg, Zi.0240; 🇩🇪 Mainz, Germany

Gastroenterologische Schwerpunkt Praxis; 🇩🇪 Mannheim, Germany

Praxis Dr. Krammer; 🇩🇪 Mannheim, Germany

Universitaetsklinikum Mannheim (Umm) - Ii Medizinische Klinik; 🇩🇪 Mannheim, Germany

Gastroenterologische Gemeinschaftspraxis Minden; 🇩🇪 Minden, Germany

Klinikum Der Universitat Munchen; 🇩🇪 Munchen, Germany

Medizinische Versorgungszentrum Portal 10; 🇩🇪 Munster, Germany

Gastroenterologische Fachpraxis Am Germania Campus; 🇩🇪 Munster, Germany

Praxiszentrum Alte Malzerei; 🇩🇪 Regensburg, Germany

Eric Norgaard Jorgensen; 🇩🇪 Remscheid, Germany

Gpr Mvz Gastroenterologie; 🇩🇪 Russelsheim, Germany

Gemeinschaftspraxis - Endoskopiezentrum M. Hasenstein; 🇩🇪 Saarbrucken, Germany

Gastroenterologische Gemeinschaftspraxis - Stade; 🇩🇪 Stade, Germany

Uni-Klinik Tubingen; 🇩🇪 Tubingen, Germany

Gastro Data Gbr; 🇩🇪 Wiesbaden, Germany

University and General Hospital of Alexandroupoli; 🇬🇷 Alexandroupoli, Greece

General Hospital of Athens 'Evangelismos'; 🇬🇷 Athens, Greece

General and University Hospital of Western Athens 'Attiko'; 🇬🇷 Athens, Greece

St. Panteleimon General Hospital of Nikaia; 🇬🇷 Athens, Greece

University and General Hospital of Heraklion; 🇬🇷 Heraklion, Greece

University Hospital of Ioannina - Division of Gastroenterology; 🇬🇷 Ioannina, Greece

Theagenio Hospital of Thessaloniki; 🇬🇷 Thessaloniki, Greece

Mercy University Hospital Cork; 🇮🇪 Cork, Ireland

St. Vincent'S University Hospital; 🇮🇪 Dublin 4, Ireland

Mater Misericordiae University Hospital; 🇮🇪 Dublin 7, Ireland

St James Hospital; 🇮🇪 Dublin 8, Ireland

Beaumont Hospital; 🇮🇪 Dublin, Ireland

National University of Ireland Galway; 🇮🇪 Galway, Ireland

Haemek Medical Center; 🇮🇱 Afula, Israel

Soroka University Medical Center (Sumc); 🇮🇱 Beer Sheva, Israel

Rambam Health Care Campus (Rhcc) - Institute of Gastroenterology; 🇮🇱 Haifa, Israel

Bnai Zion Mc; 🇮🇱 Haifa, Israel

Clalit Health Services - Lev Talpiot; 🇮🇱 Jerusalem, Israel

Meir Medical Center; 🇮🇱 Kfar Saba, Israel

Tel Aviv University - Rabin Medical Center - Beilinson Hospital; 🇮🇱 Petach Tikva, Israel

Clalit Medical Services - Migdal Hamea; 🇮🇱 Tel Aviv, Israel

Maccabi Healthcare Services; 🇮🇱 Tel Aviv, Israel

Tel Aviv Medical Center; 🇮🇱 Tel Aviv, Israel

Assaf Harofeh Medical Center (Ahmc) - Institute of Gastroenterology; 🇮🇱 Zrifin, Israel

Ospedale Civile Giuseppe Moscati; 🇮🇹 Avellino Campania, Italy

Spedali Civili Gastroenterology Unit University of Brescia; 🇮🇹 Brescia, Italy

Fondazione Poliambulanza; 🇮🇹 Brescia, Italy

Azienda Ospedaliera Per Lemergenza Cannizzaro; 🇮🇹 Catania, Italy

Azienda Ospedaliero-Universitaria Careggi (Aouc); 🇮🇹 Firenze, Italy

Casa Sollievo Della Sofferenza; 🇮🇹 Foggia 0301, Italy

Ospedale Morgagni Pierantoni Forli U.O. Gastroenterologia Ed Endoscopia; 🇮🇹 Forli, Italy

Policlinico G Martino; 🇮🇹 Messina, Italy

Asst Fatebenefratelli Sacco; 🇮🇹 Milano 3901, Italy

A.O. Guido Salvini Di Garbagnate Milanese; 🇮🇹 Milano, Italy

Fondazione Irccs Ca' Granda Osp Magg Policlinico; 🇮🇹 Milano, Italy

Universita Federico Ii; 🇮🇹 Napoli 2007, Italy

Ospedale Maggiore Della Carita; 🇮🇹 Novara, Italy

Policlicnico Universita Paolo Giaccone; 🇮🇹 Palermo, Italy

Ao San Camillo Forlanini; 🇮🇹 Roma, Italy

Ospedale Nuovo Regina Margherita; 🇮🇹 Roma, Italy

Ospedale Sandro Pertini; 🇮🇹 Roma, Italy

Fondazione Policlinico Universitario A. Gemelli; 🇮🇹 Roma, Italy

Ospedale San Filippo Neri; 🇮🇹 Roma, Italy

Universita Campus Bio-Medico; 🇮🇹 Rome, Italy

Policlinico Tor Vergata; 🇮🇹 Rome, Italy

Universita Di Salerno Aou San Giovanni Di Dio E Ruggi D'Aragona; 🇮🇹 Salerno, Italy

Ao Ordine Mauriziano Di Torino; 🇮🇹 Torino, Italy

Osp Di Circolo Fondazione Macchi; 🇮🇹 Varese, Italy

VUMC; 🇳🇱 Amsterdam, Netherlands

Onze Lieve Vrouwe Gasthuis; 🇳🇱 Amsterdam, Netherlands

Academisch Medisch Centrum - Mdl; 🇳🇱 Amsterdam, Netherlands

Amphia Ziekenhuis; 🇳🇱 Breda, Netherlands

Albert Schweitzer Ziekenhuis; 🇳🇱 Dordrecht, Netherlands

Erasmus Mc; 🇳🇱 Rotterdam, Netherlands

Zuyderland; 🇳🇱 Sittard, Netherlands

Nordlandssykehuset Hf Bodo; 🇳🇴 Bodo, Norway

Sykehuset Innlandet Hf Hamar; 🇳🇴 Hamar, Norway

Akershus University Hospital; 🇳🇴 Nordbyhagen, Norway

Oslo Univeristy Hospital Ulleval Hospital; 🇳🇴 Oslo, Norway

Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Epe; 🇵🇹 Lisboa, Portugal

General Hospital Celje; 🇸🇮 Celje, Slovenia

University Medical Center Maribor; 🇸🇮 Maribor, Slovenia

Hospital Univ. Germans Trias I Pujol; 🇪🇸 Badalona, Spain

Hospital de Bellvitge; 🇪🇸 Hospitalet, Spain

Hospital Universitario La Paz; 🇪🇸 Madrid, Spain

Complexo H. Pontevedra-Hospital de Montecelo; 🇪🇸 Pontevedra, Spain

Consorci Sanitari de Terrassa; 🇪🇸 Terrasa, Spain

H. Alvaro Cunqueiro; 🇪🇸 Vigo, Spain

Medical Dept, Gastroenterology Unit; 🇸🇪 Stockholm, Sweden

Karolinska Universitetssjukhuset Huddinge; 🇸🇪 Stockholm, Sweden

Danderyds Sjukhus Ab; 🇸🇪 Stockholm, Sweden

Universitaetsspital Bern - Inselspital - Universitaetsklinik Fuer Viszerale Chirurgie Und Medizin (Uvcm) - Klinik Und Poliklinik Fuer Gastroenterologie; 🇨🇭 Bern, Switzerland

Gastroenterologische Praxis Balsiger, Seibold & Partner Crohn-Colitis-Zentrum Hochhaus Lindenhofspital; 🇨🇭 Bern, Switzerland

Kantonsspital St. Gallen - Gastroenterologie; 🇨🇭 St. Gallen, Switzerland

Universitatspital Zurich; 🇨🇭 Zurich, Switzerland

Nevill Hall Hospital - Aneurin Bevan Health Board; 🇬🇧 Abergavenny, United Kingdom

Blackpool Victoria Hospital (Bvh) - Gastroenterology Department; 🇬🇧 Blackpool, United Kingdom

Bradford Teaching Hospitals; 🇬🇧 Bradford, United Kingdom

Frimley Park Hospital; 🇬🇧 Camberley, United Kingdom

University Hospitals Coventry and Warwickshire Nhs Trust - University Hospital (Walsgrave Hospital); 🇬🇧 Coventry, United Kingdom

Derby Hospitals Nhs Foundation Trust - Royal Derby Hospital (Derby City General Hospital); 🇬🇧 Derby, United Kingdom

The North West London Hospitals Nhs Trust (Nwlh) - St Mark'S Hospital; 🇬🇧 Harrow, United Kingdom

Hull and East Yorkshire Nhs Trust; 🇬🇧 Hull, United Kingdom

Airedale Nhs Foundation Trust; 🇬🇧 Keighley, United Kingdom

Forth Valley Royal Hospital; 🇬🇧 Larbert, United Kingdom

Royal Liverpool University Hospital; 🇬🇧 Liverpool, United Kingdom

Barts Health Nhs Trust; 🇬🇧 London, United Kingdom

Nhs Foundation Trust - Homerton University Hospital (Huh); 🇬🇧 London, United Kingdom

King'S College Hospital (Kch) Nhs Foundation Trust; 🇬🇧 London, United Kingdom

Manchester Royal Infirmary; 🇬🇧 Manchester, United Kingdom

Royal Gwent Hospital; 🇬🇧 Newport, United Kingdom

The University of Nottingham - Nottingham Digestive Diseases Centre (Nddc) (Wolfson Digestive Diseases Centre); 🇬🇧 Nottingham, United Kingdom

Salford Royal Nhs Foundation Trust; 🇬🇧 Salford, United Kingdom

University of Sheffield - Sheffield Teaching Hospitals Nhs Foundation Trust - Royal Hallamshire Hospital (Rhh); 🇬🇧 Sheffield, United Kingdom

The Shrewsbury and Telford Hospital Nhs Trust - Royal Shrewsbury Hospital; 🇬🇧 Shrewsbury, United Kingdom

University Hospital Southampton Nhs Foundation Trust; 🇬🇧 Southampton, United Kingdom

Pinderfields Hospital - Mid Yorkshire Hospital Trust; 🇬🇧 Wakefield, United Kingdom

Nhs Trust - Weston Area Health - Weston General Hospital; 🇬🇧 Weston-super-mare, United Kingdom

The Royal Wolverhampton Hospitals Nhs Trust - New Cross Hospital; 🇬🇧 Wolverhampton, United Kingdom

Western Sussex Hospitals Nhs Trust - Worthing Hospital; 🇬🇧 Worthing, United Kingdom