The Role of Leptin Receptors in NASH
- Conditions
- Metabolic SyndromeNonalcoholic Steatohepatitis
- Interventions
- Other: no interventions, only regular blood-draw
- Registration Number
- NCT00583999
- Lead Sponsor
- University of California, Davis
- Brief Summary
NAFLD is a spectrum of liver diseases associated with varying degrees of hepatic steatosis, inflammation, and in some cases, fibrosis. NAFLD is a common observation in all demographics, but the prevalence of NAFLD and nonalcoholic steatohepatitis (NASH) is especially high in the morbidly obese population. Leptin is a cytokine that is encoded by the ob gene and primarily secreted by adipose tissue. The production of serum leptin increases with progressive obesity. Because of this observation, there has been significant interest in potential role of leptin in NAFLD.
Our hypothesis is that we will find increased hepatic leptin and leptin receptor expression as the degree of hepatic injury worsens in NAFLD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 104
- All patients undergoing elective bariatric surgery, ages 18-65.
- non-obese patients, ages less than 18 and over 65. Pregnant patients.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description A no interventions, only regular blood-draw bariatric surgery
- Primary Outcome Measures
Name Time Method To link SLR to grade/stage of NASH 2.5 years
- Secondary Outcome Measures
Name Time Method To link SLR, leptin and adiponectin to features/components of the metabolic syndrome 2.5 years
Trial Locations
- Locations (1)
UC Davis Medical Center
🇺🇸Sacramento, California, United States