Translational Approaches to Septic Cardiomyopathy

• Conditions: Sepsis; Cardiomyopathies; Septic Shock

• Registration Number: NCT03252613
• Lead Sponsor: Samuel Brown

Brief Summary

This translational study will assess the association between septic cardiomyopathy (measured via left ventricular global longitudinal strain) and (a) inflammatory cytokine profiles, and (b) the behavior of cardiomyocytes derived from inducible pluripotent stem cells.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-19
• Study First Submitted: 2017-08-15
• Study First Submitted QC: 2017-08-15
• Study First Posted: 2017-08-17
• Status Verified: 2018-12
• Last Update Submitted: 2018-12-21
• Last Update Posted: 2018-12-24
• Primary Completion: 2019-10-27
• Study Completion: 2019-10-27

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of cytokine profile with left ventricular global longitudinal strain	Day 1	This outcome assesses the correlation between inflammatory cytokines (summarized via PCA) and septic cardiomyopathy, as assessed by left ventricular global longitudinal strain.

Secondary Outcome Measures

Name	Time	Method
Adrenergic susceptibility of pluripotent stem cell-derived cardiomyocytes	Day 1	This is a laboratory-based outcome, using pluripotent stem cell-derived cardiomyocytes, with exposure to adrenergic agonists and antagonists in vitro

Trial Locations

Locations (2)

Intermoutain Medical Center; 🇺🇸 Murray, Utah, United States

Stanford University; 🇺🇸 Stanford, California, United States