A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,720
- 试验地点
- 2
- 主要终点
- Validate resting-state fMRI (rs-fMRI) mapping of language and motor (hand and tongue) areas obtained by using the software developed in this research.
研究概览
简要总结
Our preliminary work demonstrates that an integrated fMRI software solution, incorporating tb-fMRI, rs-fMRI, and CVR mapping, is clinically feasible and helps clinicians plan brain tumor resection. We have developed a novel automated seed selection method that can accurately map language networks from rs-fMRI. We hypothesize that our innovative approach to enhance, optimize, and validate our preliminary software and integrate it with an established fMRI platform will create robust solutions for clinical RSN and CVR mapping. Partnering with NordicNeuroLab (NNL) will leverage the professional software development by a seasoned commercial MRI software producer in coordination with leading clinical and research experts at MD Anderson. The research will be conducted through three specific aims:
- Develop a clinical software platform for mapping RSNs and determine optimized workflow for presurgical localization of eloquent areas.
- Develop a clinical software platform for mapping CVR and determine optimized workflow for identifying and visualizing brain areas with potential false-negative fMRI results.
- Test and validate RSN and CVR mapping software in patients undergoing neurosurgery.
详细描述
Primary Objectives:
To validate resting-state fMRI (rs-fMRI) mapping of language and motor (hand and tongue) areas obtained by using the software developed in this research: We will test the non-inferiority of rs-fMRI comparing to task-based fMRI (tb-fMRI) by using intra-operative direct cortical stimulation as the gold standard.
To test whether CVR mapping using the software developed in this research will increase confidence of fMRI mapping of language and motor (hand and tongue) areas: We will test whether the accuracy of fMRI, assessed by using intra-operative direct cortical stimulation as the gold standard, will improve after incorporating the CVR mapping.
Secondary Objectives:
To optimize the rs-fMRI and CVR mapping software during the development phases and to test feasibility of the post-processing workflow using clinical images.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient must be >/= 18 years of age;
- •patients who will undergo neurosurgical resection of brain tumors;
- •patients who will undergo presurgical fMRI as standard of care;
- •patients who on neurosurgical evaluation will undergo direct cortical stimulation (DCS) as standard of care.
- •For the retrospective study, we will review up to 1600 patients all clinical presurgical fMRI studies performed on brain tumor patients at the MD Anderson since 5/
- •The inclusion criteria:
- •patients must be >/= 18 years of age;
- •patients who had the presurgical fMRI that contained at least one task-based fMRI scan.
排除标准
- •Exclusion criteria for the prospective study:
- •patients cannot give informed consent;
- •patients cannot undergo MRI examinations;
- •patients who are indicated for speech fMRI only but cannot comply with any of the speech tasks based on the evaluation of a clinical neuropsychologist.
- •Exclusion criteria for the retrospective study:
- •all fMRI scans were contaminated by head motions (translation > 2 mm or rotation > 2 degrees);
- •only speech fMRI paradigms were performed, and patients were not able to comply with any of the speech tasks based on the evaluation of a clinical neuropsychologist.
结局指标
主要结局
Validate resting-state fMRI (rs-fMRI) mapping of language and motor (hand and tongue) areas obtained by using the software developed in this research.
时间窗: Through study completion, an average of 1 year
次要结局
未报告次要终点