Evaluating the safety and feasibility of collagen patch loaded with epicardial follistatin-like 1 (FSTL1) for treatment of myocardial ischemic injury

ational institute for medical search development (NIMAD)0 个研究点目标入组 9 人开始时间: 待定最近更新: 2022年11月21日

适应症

试验速览

暂无简介。

•Age between 18 and 80 years old
•The first-time episode of myocardial infarction (MI)
•ST-elevation on the patient's electrocardiogram (ECG)
•Recommendation of isolated coronary artery bypass (CABG) by treating cardiologists or cardiac surgeons after conducting coronary angiography
•Less than 3 months delay between MI and upcoming operation
•Ejection fraction = 20% and = 40%
•Ischemia (rather than other cardiac problems) causing heart failure
•No planning for pregnancy during the study period for female participants

•Previous history of constrictive pericarditis
•Past history of surgery on pericardium
•Being on immunosuppressive therapy
•Corticosteroid medications, or chemotherapy (or any plan for being on such treatments within the next 6 months after recruitment)
•Current or past history of cancer
•Current or previous history of autoimmune disorders
•Severe renal disorder (glomerular filtration rate < 60 ml/min/1.73 m2
•Being a candidate for any types of cardiac surgery concomitant with coronary artery bypass surgery
•Having malignant ventricular arrhythmia or atrial flutter
•Severe mitral valve stenosis or insufficiency
•Severe aortic valve stenosis or insufficiency
•Patients with poor echo views
•Severe hepatic failure or cirrhosis
•Estimated life expectancy of less than one year
•Previous history for undergoing cardiac surgery
•Any contraindication for conducting cardiac magnetic resonance image
•Any tendency for perioperative bleeding (international normalized ratio > 1.5)
•Having pulmonary disease with forced expiratory volume < 50% or diffusing capacity of the lungs for carbon monoxide < 50%
•Having dementia, Alzheimer, Parkinsonism, and/or previous stroke with physical secuela.

发起方

ational institute for medical search development (NIMAD)