Brain alterations in adolescents and adults victims of sexual abuse
- Conditions
- Post-traumatic stress disorder
- Registration Number
- RBR-82zbbb2
- Lead Sponsor
- niversidade Federal de São Paulo
- Brief Summary
To evaluate the structural, functional and metabolic changes in the brain in PTSD ( post traumatic stress disorder ), in a population of adolescents victims of sexual violence, using different modalities of Magnetic Resonance imaging (Structural, Functional, Spectroscopy and DTI-diffusion tensor imaging). Evaluate the effect of therapeutic interventions - interpersonal therapy s and sandpaly and on brain structure, functioning and metabolism.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Female
- Target Recruitment
- Not specified
Case: have been victims of sexual violence; age between 14 and 17 years; to have Post traumatic stress disorder (PTSD) diagnosis after the application of the Clinician administered PTSD scale for children and adolescents (CAPS CA) performed in the screening; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficit. Controls: did not present psychiatric diagnoses through the scale Schedule for Affective Disorders and Schizophrenia for School-Aged Children (K-SADS) , did not have a traumatic event of sexual violence through the CAPS-CA scale; do not present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; do not present decompensated clinical diseases that require intensive treatment; do not present significant intellectual deficits; absence of use of psychoactive substances in the last 6 months; not being pregnant; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficits , intelligence coeficient( IQ)below 70.
Case: present psychiatric diagnoses prior to the traumatic event of sexual violence; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; Pregnancy detected through blood test.Controls: present psychiatric diagnoses; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; pregnancy detected through blood test; have been sexually abused.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Patients victims of sexual violence under treatment (both with sandplay and with IPT - interpersonal psychoterapy ) may have structural brain changes (a decrease in the cortical thickness of the prefrontal cortex, the left insula, the left middle frontal gyrus, and a reduction in the volume of the tonsil) compared to healthy controls.
- Secondary Outcome Measures
Name Time Method Analyzes of functional magnetic resonance at rest, in the pre-treatment, may show decreased connectivity between the limbic regions and default mode network In addition, post-intervention analysis (both IPT - interpersonal psychoterapy and sandplay) may be associated with increased connectivity at rest, between limbic brain regions and the default mode network). Since measurements through magnetic resonance imaging pre and post treatment, could show hypoactivation of the default mode network, decreased connectivity between the right hippocampus and the posterior cingulate cortex.;Observe statistically significant effects (P lower than 0.05) of patients with PTSD(post traummatic stress disorder) presenting reduced fractional anisotropy in many white matter treatments when compared to controls (such as corona radiata, anterior and posterior portion of the internal capsule, genuine splenic corpus callosum, inferior longitudinal fascicle and uncinated issue).