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Clinical Trials/NCT02217605
NCT02217605CompletedNot Applicable

Investigating the Effects of an Oral Fructose Challenge on Hepatic ATP Reserves in Healthy Volunteers

Stephen Bawden2 sites in 1 country10 target enrollmentStarted: March 2011Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
10
Locations
2
Primary Endpoint
Hepatic ATP reserves following an oral fructose challenge
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The purpose of this study is to determine the effects of an oral fructose challenge on liver adenosine triphosphate (ATP) reserves using 31P magnetic resonance spectroscopy (MRS) as a potential measure measure of liver health.

Detailed Description

This study uses 31P spectra acquired from the liver in healthy subjects following a fructose drink to monitor ATP levels. This is also related to baseline BMI, liver glycogen and liver lipid levels

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Basic Science
Masking
None

Eligibility Criteria

Ages
18 Years to 30 Years (Adult)
Sex
Male
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Age 18 - 30
  • •BMI 20 - 27 kg/m^2

Exclusion Criteria

  • •Liver disease or Metabolic Disorders
  • •Metal implants (not suitable for MRI)

Outcomes

Primary Outcomes

Hepatic ATP reserves following an oral fructose challenge

Time Frame: 2 hours post prandial

Monitor hepatic ATP levels following an oral fructose challenge using 31P magnetic resonance spectroscopy

Secondary Outcomes

  • Correlate hepatic ATP depletion / recovery with BMI, liver lipids and liver glycogen(2 hours post prandial)

Investigators

Sponsor
Stephen Bawden
Sponsor Class
Other
Responsible Party
Sponsor Investigator
Principal Investigator

Stephen Bawden

CASE studentship researcher

University of Nottingham

Study Sites (2)

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