Investigating the Effects of an Oral Fructose Challenge on Hepatic ATP Reserves in Healthy Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Hepatic ATP reserves following an oral fructose challenge
研究概览
简要总结
The purpose of this study is to determine the effects of an oral fructose challenge on liver adenosine triphosphate (ATP) reserves using 31P magnetic resonance spectroscopy (MRS) as a potential measure measure of liver health.
详细描述
This study uses 31P spectra acquired from the liver in healthy subjects following a fructose drink to monitor ATP levels. This is also related to baseline BMI, liver glycogen and liver lipid levels
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age 18 - 30
- •BMI 20 - 27 kg/m^2
排除标准
- •Liver disease or Metabolic Disorders
- •Metal implants (not suitable for MRI)
研究组 & 干预措施
Fructose
Oral Fructose Challenge (75 g fructose in 500 ml water) followed by 75 minutes 31P MRS
干预措施: Fructose (Dietary Supplement)
结局指标
主要结局
Hepatic ATP reserves following an oral fructose challenge
时间窗: 2 hours post prandial
Monitor hepatic ATP levels following an oral fructose challenge using 31P magnetic resonance spectroscopy
次要结局
- Correlate hepatic ATP depletion / recovery with BMI, liver lipids and liver glycogen(2 hours post prandial)
研究者
Stephen Bawden
CASE studentship researcher
University of Nottingham