Investigation of Effectiveness of Local Antibiotic With Platelet Rich Fibrin on Third Molar Surgery Outcomes In Vivo
- Conditions
- PainImpacted Wisdom ToothStaphylococcus Aureus
- Interventions
- Diagnostic Test: DiagnosisDrug: AnalgesicProcedure: traditional osteotomiesBiological: Platelet Rich Fibrin
- Registration Number
- NCT05678296
- Lead Sponsor
- Ceren Melahat Donmezer
- Brief Summary
The aim of this study was investigate the effectiveness of Local Antibiotic Applications With Platelet Rich Fibrin on Third Molar Surgery Outcomes In Vivo and In Vitro. The study included a total of 60 patients with impacted mandibular third molar. Patients were evaluated in 3 randomly separated groups. For the first and second group, Platelets Rich Fibrin+ local antibiotics were applied into the tooth socket. For the first group, amoxicillin was applied and for the second group, clindamycin was applied. There was a control group which only Platelets Rich Fibrin was applied into the socket. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- patient with no systemic diseases, no current infection, no smoke, no pregnancy
- no inflammation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description group 1 traditional osteotomies platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth. control group Analgesic platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed. control group Diagnosis platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed. group 1 Platelet Rich Fibrin platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth. group 2 Analgesic platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth. group 2 Antibiotic platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth. group 1 Antibiotic platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth. group 2 Diagnosis platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth. group 2 traditional osteotomies platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth. control group Platelet Rich Fibrin platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed. group 1 Analgesic platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth. control group traditional osteotomies platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed. group 1 Diagnosis platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth. group 2 Platelet Rich Fibrin platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth.
- Primary Outcome Measures
Name Time Method visual analogue scale (VAS) Day 15 It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.
swelling Day 15 measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.
Trismus Day 15 Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Near east University
🇨🇾Nicosia, Lefkosa, Cyprus