Clinical , Histopathological and Immunohistochemical Correlation of Severity in Lichen Planus
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- Histopathological scoring of Lichen
研究概览
简要总结
Lichen planus (LP) is a chronic, T-cell-mediated inflammatory disorder of uncertain etiology, characterized by cytotoxic immune responses against basal keratinocytes. A novel histopathological scoring system has been proposed to objectively assess disease activity and chronicity. Langerhans cells (LCs) are thought to play a role in antigen presentation and immune activation in LP, but their exact contribution remains unclear. The interplay between CD4+ helper and CD8+ cytotoxic T cells is central to its immunopathogenesis, warranting deeper evaluation. Abnormal angiogenesis has also been implicated in sustaining chronic inflammation and lesion persistence. This study aims to correlate the clinical severity of LP with its histopathological and immunohistochemical profiles to better understand disease mechanisms and guide targeted therapy
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients of age 18years and above.
- •Treatment naive cases .
- •patients who received topical treatment for 2 weeks prior or patients on systemic therapy for 4 weeks prior
- •Patients of all gender.
排除标准
- •1 Immunologically compromised patients and Pregnant women.
结局指标
主要结局
Histopathological scoring of Lichen
时间窗: Clinical severity in histopathology
planus .
时间窗: Clinical severity in histopathology
次要结局
- To analyze the expression of CD4 , CD8, CD1a and CD 34 .(To assess correlation among clinical severity , histopathology and)
研究者
Dr Ronita Lenny
Father Muller medical college