High-flow Nasal Cannula Therapy in the Treatment of Acute Carbon Monoxide Poisoning
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 96
- 试验地点
- 2
- 主要终点
- COHb reduction at 90 minutes
研究概览
简要总结
The aim of the study is to test whether oxygen therapy delivered through high-flow nasal cannula devices in patients admitted to the emergency department for acute carbon monoxide poisoning is superior to the non-rebreathing oxygen face mask therapy with a 15 L/minute oxygen flow (currently the first-line therapy), in terms of reduction of carboxyhemoglobin (COHb) concentration and delayed neurological sequelae incidence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age v 18 years
- •Carbon monoxide intoxication as major problem leading to emergency department admission
- •Carboxyhemoglobin (COHb) concentration 10% at the time of enrolment
排除标准
- •Age < 18 years
- •Glasgow coma scale ≤ 13
- •Refusal to give consent
研究组 & 干预措施
Non-rebreathing oxygen mask group
In this group patients will be treated with standard oxygen therapy delivered through a non-rebreathing face mask with a 15 L/min flow
干预措施: Non-rebreathing oxygen mask group (Device)
High-flow nasal cannula group
Patients randomised in this group will receive oxygen therapy via a high-flow nasal cannula device with a 60 L/min flow and a 100% fraction of inspired oxygen
干预措施: High-flow nasal cannula device (Device)
结局指标
主要结局
COHb reduction at 90 minutes
时间窗: 90 minutes
Patients in the High-flow nasal cannula group and patients in the non-rebreathing oxygen mask group will be compared in terms of COHb reduction at 90 minutes. The hypothesis is that in patients treated with high flow nasal cannula the reduction in COHb at 90 minutes will be significantly different compared to patients treated with non-rebreathing oxygen mask.
次要结局
- Variation in the incidence of delayed neurologic sequelae(6 weeks)
- Variation in serum lactate concentration(6 weeks)
- Variation in serum troponin concentration(6 weeks)
- Variation in S100B levels concentration(6 weeks)