Predictors of chronic post surgical pain after inguinal hernia surgery

Not Applicable

• Conditions: Pain Sensory Thresholds; Other - Conditions of unknown or disputed aetiology (such as chronic fatigue syndrome/myalgic encephalomyelitis); Surgery - Surgical techniques

• Registration Number: ACTRN12613000077763
• Lead Sponsor: Dr Alex Konstantatos

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-01-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 128

Inclusion Criteria

1. Patients who are 18-80 years of age presenting for elective hernia surgery
2. First operation for unilateral inguinal hernia
3. Absence of strangulated or incarcerated tissue in hernial sac.

Exclusion Criteria

1. Unable to provide consent
2. Current diagnosis of persistent pain syndrome
3. Current use of opioid medication or tramadol or nonsteroidal antiinflammatories to treat persistent pain
4. Complaint of hernia site pain at rest
5. Allergy or contraindication to use of morphine or oxycodone
6. Allergy or contraindication to use of nonsteroidal antiiflammatories
7. Current use of carbamazepine, phenytoin, sodium valproate, tricyclic antidepressant medications, gabapentin, pregabalin
8. Presence of significant liver impairment (aspartate aminotransferase, alanine aminotransferase, or both >40u/L) or
Presence of significant renal impairment (creatinine >140 micromol/litre)
9. Presence of significant vascular, neurological or dermal disease affecting the upper extremities
10. Presence of uncontrolled hypertension defined by a blood pressure of greater than 150/90 mmHg on screening.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Occurrence of post herniorrhaphy pain at 2 months can be predicted with knowledge of preoperative pain processing integrity testing. We propose to use a testing which predicts wind-up like pain which is based on a technique of quantitative sensory testing. We propose using the RIII reflex, a known pain research tool, as a way of assessing for the presence of, or a higher propensity to develop wind up as it has the advantage of calculating an individualized pain threshold for each subject and then provides summated testing at a level relative to the individualized pain threshold.[preoperative and 2 months ]