Analysis of the intrahepatic immune landscape in correlation with rising portalhypertension in patients with liver cirrhosis
- Conditions
- Cirrhosis of the liver
- Registration Number
- DRKS00032558
- Lead Sponsor
- Klinik für Innere Medizin II, Uniklinik Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 330
Inclusion Criteria
Adult patients with high-grade liver fibrosis (detected by a liver biopsy or a liver stiffness measurement >15kPa)
Exclusion Criteria
Other life-threatening medical conditions, minority, pregnancy, known drug abuse or participation in drug substitution programs, inability to consent. In the prospective part, complications of liver cirrhosis are to be recorded, even if they are life-threatening.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method IgG Antibodies
- Secondary Outcome Measures
Name Time Method 1. intrahepatic T-Cell-Landscape<br>2. composition of peripheral immune-cells<br>3. composition of IgG-Antibodies