The Efficacy of Intrathecal Morphine in Patients Undergoing Robot-assisted Prostatectomy
Overview
- Phase
- Not Applicable
- Intervention
- The intravenous patient-controlled analgesia
- Conditions
- Prostatic Neoplasms
- Sponsor
- Seoul National University Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- The evaluation of pain at 24 hours after surgery
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
This study will investigate the efficacy and safety of intrathecal morphine for the patients undergoing robot-assisted prostatectomy
Detailed Description
Prostatectomy is the treatment of choice for prostate cancer. The robot-assisted prostatectomy is becoming the most popular surgical method for prostate cancer. The small incision after robot-assisted prostatectomy is thought to reduce the postoperative pain. There is few investigations for the strategy to reduce the postoperative pain of robot-assisted prostatectomy. The intrathecal morphine injection is known to reduce postoperative pain for surgeries like hepatectomy, myomectomy and open prostatectomy. This method, however, is not yet studied for the robot-assisted prostatectomy. This study will investigate the efficacy and safety of intrathecal morphine for the patients undergoing robot-assisted prostatectomy.
Investigators
Deok Man Hong
Associate professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for the open nephrectomy
Exclusion Criteria
- •Patients with renal insufficiency
- •Patients with coagulopathy
- •History of any neurologic disorder
- •History of recent infection in 2 weeks
- •History of drug abuse
- •Patients who cannot understand the usage of th intravenous patient-controlled analgesia
- •Patients using opioids due to the chronic pain
Arms & Interventions
The ITM group
The postoperative pain management includes both the intrathecal morphine injection and the intravenous patient-controlled analgesia.
Intervention: The intravenous patient-controlled analgesia
The ITM group
The postoperative pain management includes both the intrathecal morphine injection and the intravenous patient-controlled analgesia.
Intervention: The intrathecal morphine injection
The IV-PCA group
The postoperative pain management includes only the intravenous patient-controlled analgesia.
Intervention: The intravenous patient-controlled analgesia
Outcomes
Primary Outcomes
The evaluation of pain at 24 hours after surgery
Time Frame: at postoperatively 24 hours
The doctor blinded to the investigation will visit patients. The pain will be assessed at rest and at coughing using visual analogue scale.
Secondary Outcomes
- The consumption of analgesics(at postoperatively 24 hours)
- The side effects of opioids after surgery(During 72 hours after the end of surgery)
- The consumption of intraoperative opioids(From the induction of anesthesia till the emergence of anesthesia, an expected average of 4 hours)