The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on Pupillary Response and Perceptual Learning
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- NYU Langone Health
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Change in Time It Takes to Reach 90% of Asymptotic Level Performance
Study Overview
Brief Summary
This study has two parts. The study team will evaluate transcutaneous auricular vagal nerve stimulation (taVNS) and two sham settings during a passive task while measuring pupillary response. Second, the study team will assign either taVNS, sham, or no intervention during a go/no-go task and evaluate perceptual learning over three sessions which will also include measuring the pupillary response and electroencephalogram (EEG).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy individuals 18 to 65
- •Normal audiometric testing
Exclusion Criteria
- •Co-morbidities including cardiomyopathies, arrhythmias
- •Implantable devices including vagal stimulators, pacemakers
- •Presence of metallic implants
- •Pregnancy
Arms & Interventions
No Intervention (Control)
Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
Intervention: Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) (Procedure)
Sham
Intervention: Sham Stimulation (Procedure)
Outcomes
Primary Outcomes
Change in Time It Takes to Reach 90% of Asymptotic Level Performance
Time Frame: Baseline, Month 3
Will be measured during performance on a go/no-go task.
Change in Speed of Learning to Perform a Behavioral Task
Time Frame: Baseline, Month 3
Will be measured during performance on a go/no-go task.
Change in Overall Mean Peak (Pupillary Response)
Time Frame: Baseline, Month 3
Pupillary responses will be measured noninvasively using a video camera during a go/no-go task.
Secondary Outcomes
No secondary outcomes reported