The efficacy of ramelteon to prevent postoperative delirium after general anesthesia in the elderly: a randomized placebo controlled trial
- Conditions
- postoperative delirium
- Registration Number
- JPRN-UMIN000028436
- Lead Sponsor
- Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
- Brief Summary
The stratified log rank test showed no significant difference between ramelteon and placebo to prevent postoperative delirium in the elderly undergoing abdominal or thoracic surgery ( p = 0.596 ). The findings of this randomized double-blind placebo-controlled trial do not support the effect of ramelteon to prevent postoperative delirium.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 103
Not provided
Patients who are delirious on registry Patients who are currently taking ramelteon Patients who have a previous adverse reaction to ramelteon Patients who take medicine contraindicated to be coadministered with ramelteon Patients with lactose intolerance Patients who are considered non per os on postoperative day 1 Patients who are considered to be discharged within postoperative day 6 Patients who have a score less than or equal to 10 on the Mini Mental State Examination Patients who have severe hepatic damage Patients with known Dementia with Lewy bodies
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method