Screening of Individuals at risk for Peripheral Arterial Disease in lower extremity and influence of supervised exercise training on physical function and lower extremity vascularization.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 484
- 试验地点
- 1
- 主要终点
- early identification of risk factors for Peripheral Arterial Disease
研究概览
简要总结
Introduction
Peripheral arterial disease (PAD) is a circulatory condition resulting from reduced blood flow through the arteries, primarily due to atherosclerosis. PAD affects about 10-15% of the population and 20% of people over 60. Despite its prevalence, PAD is often underdiagnosed, especially in developing countries like India. PAD leads to significant physical and psychosocial impairments, increasing the risk of coronary heart disease, cerebrovascular disease, and severe limb complications.
Research Question
To investigate early screening for PAD and the impact of supervised exercise training on physical function, quality of life, and lower limb vascularisation.
Clinical Significance
Effective non-invasive screening tools for PAD are crucial, especially for asymptomatic patients, to improve prognosis. Physical activity can reduce the risk and improve survival in PAD patients. This study aims to develop a novel non-invasive screening tool and a supervised exercise training protocol to enhance physical function and vascularisation in PAD patients.
Aim of the Study
To screen individuals at risk for early signs of PAD in the lower extremities and evaluate the effect of exercise training on physical function, quality of life, and lower extremity vascularisation.
Objectives
- Identify early signs of lower extremity PAD in at-risk individuals (e.g., those with diabetes or hypertension).
- Study lower extremity vascularisation in activities such as squatting and kneeling in individuals with mild to moderate PAD.
- Compare the effect of a 12-week supervised exercise program on physical function, quality of life, and lower extremity vascularisation between a control group and an intervention group.
Conclusion
This study aims to develop a novel non-invasive tool for early diagnosis of PAD and evaluate the benefits of a supervised exercise training protocol, aiming to improve physical function, quality of life, and vascular health in PAD patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 40.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Males and females with risk factors Either Diabetes or Hypertension With one the following; Smoking, hypercholesteremia, physical Inactivity, Obesity .
- •ABI value 0.7-0.9(mild to moderate affection of Peripheral arterial disease.
排除标准
- •Dementia Induvial with cognitive impairment – inability to follow instructions Amputation Major surgery or myocardial infraction during previous three months Unstable Angina Walking limited by a condition other than leg Ischemia.
结局指标
主要结局
early identification of risk factors for Peripheral Arterial Disease
时间窗: 8 weeks
to understand lower limb vascularisation in ground level activities
时间窗: 8 weeks
to develop a supervised exercise training protocol for improving physical function and quality of life in patients with peripheral arterial diease
时间窗: 8 weeks
次要结局
- Early identification of Peripheral Arterial Disease using a Novel screening tool(screening tool)
研究者
Bhoomika Sawant
MGM School of Physiotherapy,MGM Institute of Health Sciences, Navi Mumbai