Advanced MRI in Abdominal Aortic Aneurysms

Completed

Conditions: Abdominal aortic aneurysm
local enlargement of the main abdominal artery
10002363

Registration Number: NL-OMON47558

Lead Sponsor: Chirurgie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 35

Inclusion Criteria

- Adult patients (* 18 years of age)
- AAA with a maximal aneurysm diameter of at least 30 mm

Exclusion Criteria

- Contra-indications for MRI
- Severely reduced renal function (eGFR <30)
- Previous allergic reaction to intravenous contrast agents
- Suprarenal AAA
- Pararenal AAA
- Previous aneurysm repair
- Inflammatory aneurysm
- Mycotic or other infectious aneurysm
- Vasculitis
- Connective tissue disease

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>4D flow MRI: wall shear stress (WSS);<br /><br>DCE-MRI: wall permeability, expressed by the kinetic transport constant<br /><br>(Ktrans);<br /><br>T1/T2 mapping: T1/T2 relaxation time</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>4D flow:<br /><br>- Peak flow velocity inside the aneurysm<br /><br>- Location of peak wall shear stress<br /><br>- Flow velocity at aneurysm entrance<br /><br>- Descriptive flow patterns<br /><br>- Oscillatory shear index<br /><br><br /><br>DCE-MRI:<br /><br>- Quantitative reverse reflux rate constant kep<br /><br>- Area under the curve of contrast uptake<br /><br>- Peak enhancement ratio<br /><br>- Wash-in slope<br /><br>- Time to peak (TTP)<br /><br>- Mean transit time (MTT)<br /><br><br /><br>T1/T2 mapping:<br /><br>- No secondary parameters</p><br>