Glycemic Control Before, During and After the 2016 Paris Marathon in 12 Patients With Type 1 Diabetes Using Continuous Glucose Monitoring
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- AUC > 200 mg/dl and <70mg/dl during Marathon
研究概览
简要总结
This is an observational mono-centric retrospective study carried out at the University Hospital of Brest The main objective of this study is to assess the glycemic control before, during and after the 2016 Paris Marathon in patients with type 1 diabetes using continuous glucose measurement (CGM) by DEXCOM sensor.
详细描述
Introduction
In patients with type 1 diabetes, there are general recommendations in the literature regarding carbohydrate intake and reduction of insulin doses in case of physical activity, but these recommendations should be tailored to individual patients. However, there is limited data on methods that could be applied in case of intense or extreme physical activity in patients with type 1 diabetes.
The diabetes department of Brest University Hospital has received many requests from type 1 diabetic patients for individual adaptation of insulin and carbohydrate consumption in order to participate in extreme sporting events such as marathons. One group of patients wanted to run the 2016 Paris Marathon. Our service had offered them support to define a validated method to optimize their glycemic control and prevent acute metabolic complications through 2 preparatory races preceding the Marathon de Paris 2016.
The main objective of this study is to assess the glycemic control before, during and after the 2016 Paris Marathon using continuous glucose measurement (CGM) by DEXCOM sensor.
Methods:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Type 1 diabetes for more than 3 months
- •who ran the 2016 Paris Marathon;
排除标准
- •other than type 1 diabetes;
- •uncontrolled diabetes with HbA1c> 9%;
- •Pregnancy;
- •Coronary heart disease contraindicated for marathon running;
结局指标
主要结局
AUC > 200 mg/dl and <70mg/dl during Marathon
时间窗: up to five days
Area under the curve (AUC in mg/dl/min) in hyperglycemia (AUC \> 200 mg/dl) and hypoglycemia (AUC \< 70 mg/dl)) over 3 periods: in the 24 hours before, during and within 72 hours after the Marathon.
Time spent in hyper and hypoglycemia during Marathon
时间窗: up to five hours
Percentage of time spent with blood glucose \>200mg/dl, \[70-200mg/dl\] and \<70mg/dl) during the Marathon
次要结局
- Carbohydrate intake(up to 1 day)
- Insulin doses(up to five days)
- AUC > 200 mg/dl and <70mg/dl during PR1 and PR2(up to five days)
- Time spent in hyper and hypoglycemia during PR1 and PR2(up to five hours)