A Comparison of Cognitive Training Approaches in Psychotic Disorders

Not Applicable

Completed

• Conditions: Psychotic Disorders
• Interventions: Behavioral: Cognitive Remediation - Perceptual Training; Behavioral: Cognitive Remediation - Executive Training

• Registration Number: NCT03024203
• Lead Sponsor: Queen's University

Brief Summary

Cognitive remediation (CR) is the best treatment to improve neurocognitive abilities for individuals with psychosis, however, there is no gold standard method of cognitive remediation available. Cognitive training refers to the training component of CR in which people practice computerized exercises that train specific cognitive abilities. There is no agreed upon approach within the field as to the type of training that is most effective with some studies, training higher level cognitive abilities, some training perceptual abilities, and others training general cognitive skills. This study will directly compare two competing methods of cognitive training on measures of neurophysiology, neurocognition, functional competence, and real-world functional performance.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08
• Study First Submitted: 2016-10-27
• Study First Submitted QC: 2017-01-15
• Study First Posted: 2017-01-18
• Primary Completion: 2018-03
• Study Completion: 2018-03
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-12
• Last Update Posted: 2018-11-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• psychotic disorder
• No previous cognitive remediation in past 6 months

Exclusion Criteria

• Brain injury
• Substance abuse
• Neurocognitive disorder
• Developmental Disability

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Perceptual Training	Cognitive Remediation - Perceptual Training	Perceptual Training (PT) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. PT will be delivered in both individual and group settings.
Executive Training	Cognitive Remediation - Executive Training	Executive Training (ET) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. ET will be delivered in both individual and group settings.

Primary Outcome Measures

Name	Time	Method
Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline	Post-treatment (within 2 weeks following the end of treatment)	Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks

Secondary Outcome Measures

Name	Time	Method
Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline	Follow-Up (3 months after the end of treatment)	The MCCB is the gold standard cognitive assessment for schizophrenia research
Change in Neurophysiology - EEG from Baseline	Follow-Up (3 months after the end of treatment)	Alpha and Theta band synchronization, p300, mismatch negativity
Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline	Follow-Up (3 months after the end of treatment)	Performance based measure of real life functional skills using role-play
Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline	Follow-Up (3 months after the end of treatment)	Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks

Trial Locations

Locations (1)

Queen's University; 🇨🇦 Kingston, Ontario, Canada