Sensory Memory in Speech Motor Learning

Not Applicable

Recruiting

• Conditions: Consolidation; Speech
• Interventions: Behavioral: Adaptation; Other: cTBS

• Registration Number: NCT04818268
• Lead Sponsor: Yale University

Brief Summary

The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.

Detailed Description

This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2019-08-01
• Study First Submitted: 2021-03-19
• Study First Submitted QC: 2021-03-23
• Study First Posted: 2021-03-26
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-21
• Last Update Posted: 2024-03-25
• Primary Completion: 2025-07-31
• Study Completion: 2025-07-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• right handed adults
• no known physical or neurological abnormalities

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Exclusion Criteria

• patients with:
• cardiac pacemaker
• surgical clips or values on the heart
• implants
• metal or metallic fragments in any part of the body
• pregnancy
• claustrophobia
• a personal or family history of epilepsy
• currently taking antipsychotic drugs
• currently taking antidepressant drugs
• currently taking antianxiety drugs
• history of concussion.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Adaptation to Altered Auditory Feedback + cTBS to 46v	Adaptation	Adaptation to Altered Auditory Feedback + cTBS to 46v
Adaptation to Altered Auditory Feedback	Adaptation	Adaptation to Altered Auditory Feedback
Sensory Memory + cTBS to 46v	Adaptation	Sensory Memory + cTBS to 46v
Sensory Memory + cTBS to 46v	cTBS	Sensory Memory + cTBS to 46v
Somatosensory Sensory Memory	Adaptation	Somatosensory Sensory Memory
Adaptation to Altered Auditory Feedback + cTBS to 46v	cTBS	Adaptation to Altered Auditory Feedback + cTBS to 46v
Auditory Sensory Memory	Adaptation	Auditory Sensory Memory

Primary Outcome Measures

Name	Time	Method
Sensory Memory	Single day experiment	Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory.
Speech Motor Learning	Performance as measured at the end of learning (single day experiment)	Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation.

Trial Locations

Locations (1)

McGill University; 🇨🇦 Montréal, Quebec, Canada