Role of Sensory Working Memory in Speech Motor Learning Aim 2
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Yale University
- Enrollment
- 120
- Locations
- 2
- Primary Endpoint
- Sensory Memory
Study Overview
Brief Summary
The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.
Detailed Description
This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 21 Years to 40 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •right handed adults
- •no known physical or neurological abnormalities
Exclusion Criteria
- •patients with:
- •cardiac pacemaker
- •surgical clips or values on the heart
- •metal or metallic fragments in any part of the body
- •pregnancy
- •claustrophobia
- •a personal or family history of epilepsy
- •currently taking antipsychotic drugs
- •currently taking antidepressant drugs
- •currently taking antianxiety drugs
- •history of concussion.
Arms & Interventions
Sensory Memory + cTBS to 46v
Sensory Memory + cTBS to 46v
Intervention: cTBS (Other)
Sensory Memory + cTBS to 46v
Sensory Memory + cTBS to 46v
Intervention: Adaptation (Behavioral)
Adaptation to Altered Auditory Feedback
Adaptation to Altered Auditory Feedback
Intervention: Adaptation (Behavioral)
Auditory Sensory Memory
Auditory Sensory Memory
Intervention: Adaptation (Behavioral)
Somatosensory Sensory Memory
Somatosensory Sensory Memory
Intervention: Adaptation (Behavioral)
Adaptation to Altered Auditory Feedback + cTBS to 46v
Adaptation to Altered Auditory Feedback + cTBS to 46v
Intervention: Adaptation (Behavioral)
Adaptation to Altered Auditory Feedback + cTBS to 46v
Adaptation to Altered Auditory Feedback + cTBS to 46v
Intervention: cTBS (Other)
Outcomes
Primary Outcomes
Sensory Memory
Time Frame: Single day experiment
Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory.
Speech Motor Learning
Time Frame: Performance as measured at the end of learning (single day experiment)
Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation.
Secondary Outcomes
No secondary outcomes reported