Respiratory bacteria and viruses in the nasopharynx of infants and parents.
Completed
- Conditions
- Asymptomatic pneumococcal carriage, infectious diseases, Streptococcus pneumoniae, viral presence, bacterial commensals
- Registration Number
- NL-OMON28043
- Lead Sponsor
- ational Institute for Public Health and the Environment (RIVM)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 990
Inclusion Criteria
1. Healthy infants;
2. Parents are willing and able to participate;
Exclusion Criteria
Infants:
1. Previous vaccinations not according to Dutch 3+1 schedule;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The percentage of total vaccine- and non-vaccine pneumococcal serotypes found in the nasopharyngeal swabs from infants at 11 and 24 months of age by conventional culture. Serotyping is performed at single<br>colony level by Quellung reaction as in previous surveillance studies.
- Secondary Outcome Measures
Name Time Method 1. The percentage of total vaccine- and non-vaccine pneumococcal serotypes found in the nasopharyngeal swabs from parents of the 24-month-old infants as determined by culture and Quellung;<br /><br>2. The percentage of infants and parents with nasopharyngeal swabs positive for S. aureus, H. influenzae and M. catarrhalis as determined by culture;<br /><br>3. The percentage of individual pneumococcal serotypes found in the nasopharyngeal swabs from infants at 11 and 24 months of age and parents of the 24-month-old infants as determined by culture and Quellung.