Use of trans cranial doppler to titrate norepinephrine for optimal cerebral perfusion in septic shock
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- To titrate norepinephrine infusion using Trans cranial Doppler variable, pulsatility index ,to maintain optimal cerebral perfusion in septic shock and to assess the neurological outcome when TCD is used to titrate the norepinephrine infusion.
研究概览
简要总结
Cerebral perfusion is altered during early sepsis. Transcranial doppler ultrasound (TCD) reflects cerebral blood flow velocities which may be considered a surrogate for cerebral perfusion. Cerebral perfusion can be assessed by transcranial doppler ultrasound (TCD). Norepinephrine, while increasing mean arterial pressure (MAP), has been shown to restore cerebral blood flow (CBF), which can be assessed using TCD.TCD being a non invasive tool proves as a surrogate for cerebral perfusion pressure and thus guide the resuscitation and titration of norepinephrine dose for adequate and CPP and assess the neurological outcomes due to poor cerebral perfusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient admitted to Intensive Care Units with early septic shock defined as within 6 hours of start of norepinephrine infusion.
排除标准
- •Age less than eighteen years Negative consent for participation in study Known cerebrovascular lesions and events like ischemic or hemorrhagic stroke History of head injury or other causes of increased ICP Known cerebral infection Known severe Carotid artery stenosis Other causes leading to encephalopathy.
结局指标
主要结局
To titrate norepinephrine infusion using Trans cranial Doppler variable, pulsatility index ,to maintain optimal cerebral perfusion in septic shock and to assess the neurological outcome when TCD is used to titrate the norepinephrine infusion.
时间窗: Day 0, Day 1, Day 3 and after inotropes are stopped
次要结局
- â— Assessment of change in neurological status in patients with septic shock when PI is used to titrate norepinephrine dose.(â— To assess the impact of TCD derived titration of nor epinephrine on length of ICU stay, ventilator free days, & outcome.)
研究者
JASMINE KAUR KOCHHAR
Dayanand Medical College and Hospital, Ludhiana