NCT00125294已完成1 期
Evaluation of a Dose Titration Protocol for Sublingual Methadone Hydrochloride for the Management of Cancer-related Breakthrough Pain
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 10
- 主要终点
- Determine assessment protocol
研究概览
简要总结
A dose titration protocol for sublingual methadone hydrochloride for the management of cancer-related breakthrough pain to find the optimal dose.
详细描述
This is a dose titration protocol for sublingual methadone hydrochloride for the management of cancer-related breakthrough pain to find the optimal dose.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •> 18 years of age
- •Experiences episodes of breakthrough pain which respond to opioid therapy
- •Controlled baseline pain
- •Cognitive status sufficient for accurate completion of assessment form
- •Willing to provide written informed consent
- •Ability to hold a volume of 1 cc of water under the tongue for 5 minutes
排除标准
- •Currently or has received methadone during the previous week
- •Recent history of substance abuse
- •Severe respiratory impairment or other contraindications to opioids
- •Recently received therapies that had the potential to alter pain intensity or response to analgesics
- •Symptomatic anemia
结局指标
主要结局
Determine assessment protocol
Determine optimal dose titration
次要结局
未报告次要终点
研究者
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