Sonographic assessment of diaphragm function during inspiratory loading.

Completed

• Conditions: breathing muscle weakness; diaphragm fatigue; 10013369

• Registration Number: NL-OMON41151
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

- age > 18 year
- informed consent
- body mass index < 25

Exclusion Criteria

- pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including diabetes and auto-immune diseases
- pre-existent lung disease
- upper airway / esophageal pathology
- recent (< 1 month) nasal bleeding
- phrenic nerve lesions
- any metals in body (pacemaker, splinters, metal stiches).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in sonographic muscle deformation and velocity (i.e. strain and strain<br /><br>rate) during inspiratory loading.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- sonographic fractional thickening of the diaphragm during inspiratory loading<br /><br>- peak activity of diaphragm electromyography during inspiratory loading<br /><br>- center frequency of diaphragm electromyography during inspiratory loading<br /><br>- transdiaphragmatic pressure during inspiratory loading<br /><br>- transdiaphragmatic twitch pressure before/after inspiratory loading<br /><br>- tidal volume / minute ventilation during inspiratory loading</p><br>