BIOScavenger Therapy in Organophosphate Poisoning

Completed

• Conditions: Organophosphate poisoning; Injury, Occupational Diseases, Poisoning; Toxic effect of pesticides

• Registration Number: ISRCTN84835351
• Lead Sponsor: South Asian Clinical Toxicology Research Collaboration (SACTRC) (Sri Lanka)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-01-28
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients (both males and females) above 15 years who present to the Emergency Department of Christian Medical College and Hospital (CMCH) with a diagnosis of organophosphate poisoning made on the basis of:
1. The typical clinical toxidrome of cholinergic and nicotinic manifestations
2. Reliable identification of the compound ingested based on the container brought by patient attendants or a subsequent confirmation by serum pseudocholinesterase levels of less than 1000 IU/

Exclusion Criteria

1. Those who present more than 12 hours after having consumed the OP poison (late presenters)
2. Those who are suspected to have taken a combination of poisons/tablets along with the OP (poly-substance overdose)
3. Those who are already treated with oximes in other hospitals prior to coming here (prior oxime therapy). This is because we do not want to have more than one intervention which can affect outcomes.
4. Those who are pregnant or lactating
5. Those who do not give consent for the study
6. Those who have a pre-existing volume overloaded state
7. Those who have a cardiac arrest within 15 minutes of arrival in the emergency department

Study & Design

• Study Type: Interventional
• Study Design: Not specified