NCT03085602已完成不适用
Smoking Cessation, Cognitive Control and Reward Processing: An fMRI Pilot Study
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Change in activation in reward processing regions of the brain
研究概览
简要总结
The purpose of this research study is to examine changes in brain regions associated with cognitive control and reward processing during behavioral smoking cessation treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •smoke > 10 cigarettes per day
- •vision is normal or corrected-to-normal
排除标准
- •serious medical illness unsuitable for the MR scanner based on best clinical judgment
- •any neurologic or psychiatric disorder
- •known heart disease
- •high blood pressure
- •currently taking psychotropic or cardiovascular medication
- •history of alcohol or other substance dependence or current abuse
- •risk for hazard due to magnetic fields such as metal in the body surgically or accidentally (e.g., pacemaker, cochlear implants, aneurysm clips, intravascular stents or coils, spinal shunt, injury involving bullets, shrapnel or metal implanted in their body, etc)
- •pregnancy
研究组 & 干预措施
CBT Treatment
Experimental
Participants receive Cognitive behavioral therapy (CBT). Participants will receive 4 one hour CBT treatments.
干预措施: Cognitive behavioral therapy (Behavioral)
Control Group
Active Comparator
Participants receive health education treatment. Participants will attend treatment sessions that match the CBT Treatment arm with respect to time and contact.
干预措施: Health education (Behavioral)
Control Group - Scans
No Intervention
Participants in this new arm to the study will receive no intervention and will receive three scans.
结局指标
主要结局
Change in activation in reward processing regions of the brain
时间窗: Change from Baseline to Week 4
次要结局
- Change in activation in cognitive control regions of the brain(Change from Baseline to Week 4)
- Change in connectivity between reward and cognitive control regions of the brain(Change from Baseline to Week 4)
研究者
研究点 (1)
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