The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS)
Withdrawn
- Conditions
- Cyclic Vomiting Syndrome
- Registration Number
- NCT00728104
- Lead Sponsor
- Medical College of Wisconsin
- Brief Summary
This is a study with the principle goal being to learn about the use of L-Carnitine and CoQ10, two vitamin supplements that are currently being used to treat Cyclic Vomiting Syndrome, largely initiated by parents. We want to learn how effective these supplements are compared to standard treatment, at what dose, and what onset of action in order to initiate future prospective study on these supplements.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- 3 discrete episodes of vomiting
- normal health between episodes
- stereotypical clinical pattern
- no abnormal test results to account for vomiting (see exclusion criteria)
Exclusion Criteria
- abnormal UGI with small bowel follow-through revealing an anatomic anomaly, inflammatory or obstructive
- Significantly abnormal endoscopic biopsies (moderate to severe esophagitis, H. pylori)
- Abnormal abdominal ultrasound revealing hydronephrosis, cholelithiasis, pancreatitis
- Positive screening for endocrine disorder (diabetic ketoacidosis, Addison's)
- Positive screening for inborn errors of metabolism (hypoglycemia, lactic acidosis, hyperammonemia, organic acidemia, amino aciduria, elevated beta-ALA, porphobilinogen)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method How two vitamin supplements are being used to treat cyclic vomiting syndrome Two years
- Secondary Outcome Measures
Name Time Method How effective these supplements appear to be compared to standard treatment Two years
Trial Locations
- Locations (1)
Children's Hospital of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States