Analysis of Protein and Emotional Alterations During and After Hypobaric Hypoxia

Not Applicable

Completed

• Conditions: Hypoxia, Altitude

• Registration Number: NCT03823677
• Lead Sponsor: Universitätsklinikum Köln

Brief Summary

This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.

Detailed Description

This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.

15 different Groups are analysed: control Group, 5000ft Group, 8000 ft Group, 10000ft Group and 15000ft Group - all for 15, 30, and 60 minutes.

Study Timeline

• Study Start: 2018-07-01
• Study First Submitted: 2019-01-07
• Study First Submitted QC: 2019-01-29
• Study First Posted: 2019-01-30
• Primary Completion: 2022-04-30
• Study Completion: 2022-04-30
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-16
• Last Update Posted: 2022-05-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 250

Inclusion Criteria

• Helathy

Exclusion Criteria

• Ear problems

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Protein Expression before hypoxia	Measurement immediately 1 minute before of hypoxia/experiment	proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics
Emotional assessment tears	Measurement starts immediately with hypoxia in the pressure chamber. duration 10 minutes	Emotional tears test
Emotional assessment	Measurement in the pressure chamber after tears test (i.e. 10 minutes after start). duration 10 minutes	Emotional stroop test; Williams, J. M. G., Mathews, A., \& MacLeod, C. (1996). The emotional Stroop task and psychopathology. Psychological Bulletin, 120, 3-24.
Protein Expression after hypoxia	Measurement immediately and at termination (i.e., 1 minute after) of hypoxia/experiment	proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics
Emotional assessment mood	Measurement in the pressure chamber after stroop test (i.e. 20 minutes after start). duration 10 minutes	Emotional mood test, POMS mood score. Shukitt-Hale, B., Banderet, L.E., \& Lieberman, H.R. (1998). Elevation-dependent symptom, mood, and performance changes produced by exposure to hypobaric hypoxia, The International Journal of Aviation Psychology, 8, 319-334,

Trial Locations

Locations (1)

University Hospital of Cologne; 🇩🇪 Cologne, NRW, Germany