Analysis of Protein and Emotional Alterations During and After Hypobaric Hypoxia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 250
- 试验地点
- 2
- 主要终点
- Protein Expression before hypoxia
研究概览
简要总结
This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.
详细描述
This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.
15 different Groups are analysed: control Group, 5000ft Group, 8000 ft Group, 10000ft Group and 15000ft Group - all for 15, 30, and 60 minutes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
盲法说明
volunteers
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Ear problems
结局指标
主要结局
Protein Expression before hypoxia
时间窗: Measurement immediately 1 minute before of hypoxia/experiment
proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics
Emotional assessment tears
时间窗: Measurement starts immediately with hypoxia in the pressure chamber. duration 10 minutes
Emotional tears test
Emotional assessment
时间窗: Measurement in the pressure chamber after tears test (i.e. 10 minutes after start). duration 10 minutes
Emotional stroop test; Williams, J. M. G., Mathews, A., \& MacLeod, C. (1996). The emotional Stroop task and psychopathology. Psychological Bulletin, 120, 3-24.
Protein Expression after hypoxia
时间窗: Measurement immediately and at termination (i.e., 1 minute after) of hypoxia/experiment
proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics
Emotional assessment mood
时间窗: Measurement in the pressure chamber after stroop test (i.e. 20 minutes after start). duration 10 minutes
Emotional mood test, POMS mood score. Shukitt-Hale, B., Banderet, L.E., \& Lieberman, H.R. (1998). Elevation-dependent symptom, mood, and performance changes produced by exposure to hypobaric hypoxia, The International Journal of Aviation Psychology, 8, 319-334,
次要结局
未报告次要终点
研究者
Jochen Hinkelbein
Clinical Professor
Universitätsklinikum Köln