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临床试验/CTRI/2025/09/095387
CTRI/2025/09/095387尚未招募Phase 3 4

Comparative evaluation of the adjunctive use of ozone therapy, antimicrobial photodynamic therapy and topical oxygen-releasing gel compared to scaling and root planing alone: a single blinded randomized controlled trial.

Dr Nidhi Anand1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2025年10月21日最近更新:

试验速览

阶段
Phase 3 4
状态
尚未招募
发起方
入组人数
120
试验地点
1
主要终点
Reduced probing depth

研究概览

简要总结

Patients with moderate to severe periodontitis will be selected for this study. Randomization will be done and patients will be divided into four groups. Test Group A will receive Scaling and Root Planing (SRP) along with Ozone Therapy, test group B will receive SRP along with antimicrobial photodynamic therapy, test group C will receive SRP along with oxygen releasing gel while Control Group (D) will receive SRP alone. The parameters will be assessed at baseline, 6 weeks, 4 months and 6 months. All the adjunctive therapies will be reapplied in the respective test groups at the 4th month. The patients will be kept on follow up for a period of 6 months to evaluate reduction in probing pocket depth and gain in relative clinical attachment level.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
Participant Blinded

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • Participants diagnosed with moderate to severe periodontitis will be included.
  • Eligible individuals must have at least 16 teeth, with a minimum of four teeth present in each quadrant.
  • Participants should be between 18 and 65 years of age.

排除标准

  • History of antibiotic use within the previous 6 months.
  • History of periodontal therapy within the last 12 months.
  • Presence of uncontrolled systemic diseases.
  • Presence of respiratory diseases.
  • Current daily smokers.
  • Pregnant or lactating women.
  • Presence of cervical caries or cervical restorations.
  • Ongoing orthodontic therapy.

结局指标

主要结局

Reduced probing depth

时间窗: At baseline, 6 weeks, 4 months, 6 months

次要结局

  • relative attachment level(6 weeks, 4 months, 6 months)

研究者

发起方
Dr Nidhi Anand
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr Nidhi Anand

Government Dental College and Hospital, Jamnagar

研究点 (1)

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