Clinical Efficacy of NST With Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.

Not Applicable

Not yet recruiting

• Conditions: Periodontitis, Adult

• Registration Number: NCT07184268
• Lead Sponsor: Cairo University

Brief Summary

The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males and females in the age group between 18 and 50 years. outcome measures are Clinical attachment level (CAL), plaque index (PI), gingival index (GI).

Detailed Description

Periodontitis is an advanced periodontal disease with a distinctive clinical signs and symptoms as rapid attachment loss and bone destruction

The primary treatment approach for periodontitis is mechanical plaque removal through debridement, particularly scaling and root planing (SRP) using hand or ultrasonic instruments.

curcumin gel is an adjunct to non-surgical periodontal therapy is a highly potent local antioxidant and anti-inflammatory agent. While ozone has a potent antimicrobial and anti-inflammatory effects it also can be incorporated into a lipid carrier such as olive oil. Ozone's stability and ease of application are markedly enhanced. Ozonized olive oil can be formulated into a gel with ideal rheological properties for injection into periodontal pockets.

Study Timeline

• Status Verified: 2025-09
• Study First Submitted: 2025-09-08
• Study First Submitted QC: 2025-09-14
• Last Update Submitted: 2025-09-14
• Study First Posted: 2025-09-19
• Last Update Posted: 2025-09-19
• Study Start: 2025-11-01
• Primary Completion: 2026-03
• Study Completion: 2026-03-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Patients diagnosed with stage II periodontitis defined by having interdental CAL 3-4 mm and presence of pocket depth (PD) ≤ 5 mm, and grade B periodontitis characterized by a moderate rate of disease progression.
2. Patients agree to a 3-month follow-up period and provide an informed consent.

Exclusion Criteria

1. Presence of prosthetic crowns, overhanging restorations and orthodontic treatment.
2. Teeth with both endo-perio lesions.
3. Antibiotics therapy that has an impact on the clinical signs and symptoms of periodontitis in the previous 3 months.
4. Anti-inflammatory drugs in the previous 1 month.

6. History of systemic disease, allergy, cardiovascular diseases, diabetes mellitus, hypertension, bleeding disorders, hyperparathyroidism, and compromised medical conditions, pregnant and lactating females.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Clinical attachment level	3 months	measured from the cementoenamel junction (CEJ) to the bottom of pocket.

Secondary Outcome Measures

Name	Time	Method
Gingival Index	3 months	Index scores will be recorded showing gingival bleeding and inflammation
Plaque index	3 months	be used to evaluate plaque accumulation