JPRN-UMIN000002568已完成2 期
The vaccine therapy for chronic hepatitis B - The vaccine therapy for chronic hepatitis B
Department of Gastroenterology and Metabolism, Hiroshima university0 个研究点目标入组 10 人开始时间: 2009年9月30日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 10
研究概览
简要总结
Eight chronic hepatitis B patients, who had received long-term nucleotide analogue treatment, were treated with monthly HBIG injections as an additional treatment. After 1 year of treatment, an HBsAg level reduction of more than 1 log IU/mL was observed in four patients, and three patients became anti-HBs positive. No adverse events occurred during HBIG therapy.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- ot applicable 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. Hypersensitivity to nucleotide analogues, HBIG, HB vaccine or any other vaccines 2. Pregnant or nursing 3. Heart disease with uncontrolled status 4. Severe acute disease 5. Fever more than 37.5C 6. Renal dysfunction 7. IgA deficiency 8. Anemia caused by hemolysis or the loss of blood 9. Immunocompromised of immunosuppressive status 10. Chronic liver dysfunction except for HBV infection 11. The others who were disqualified to entry this trial by attending physicians
研究者
相似试验
已完成
不适用
Therapeutic vaccination for chronic hepatitis B virus infection in AfricaISRCTN67270384niversity of Oxford (UK)77
Unknown
1 期
A Clinical Trial on Hepatitis B Vaccine Activated-Dendritic Cells Combined With Anti-HBV Drugs in CHBChronic Hepatitis BNCT02615639Third Affiliated Hospital, Sun Yat-Sen University450
Unknown
不适用
Terminator 2 RegisterChronic Hepatitis B, HBeAg NegativeNCT03643172Hannover Medical School50
招募中
不适用
Hepatitis B vaccination for patients with chronic hepatitis BChronic hepatitis BJPRN-UMIN000005978Kyoto University20
Enrolling By Invitation
不适用
A Follow-up Study of Peginterferon Alfa-2b Combined With TDF in Patients With Chronic Hepatitis BChronic Hepatitis BNCT06707922Xiamen Amoytop Biotech Co., Ltd.350