Proton Pump Inhibitor Use is Associated With High Risk of Pneumonia in Chronic Kidney Disease Patients

Completed

• Conditions: Chronic Kidney Disease; Pneumonia

• Registration Number: NCT01588886
• Lead Sponsor: Far Eastern Memorial Hospital

Brief Summary

Chronic kidney disease is a severe medical problem in Taiwan public health issue, which the highest incidence and prevalence rate in the world.Proton pump inhibitors may increase the risk of pneumonia appearance, which were caused by profound irreversible gastric acid suppression. The study purpose was to characterize difference of developing pneumonia in chronic kidney disease of prior use proton pump inhibitors.

Detailed Description

The study used data from Taiwan Health Insurance Research Database; the investigators conducted a population-based cohort study in Taiwan. Case consisted of all patients who had a first diagnosis of chronic kidney disease for the period between 1997 and 2008. The investigators utilized the use of Proton pump inhibitor from chronic kidney disease patients.

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2012-04-27
• Study First Submitted QC: 2012-04-30
• Study First Posted: 2012-05-01
• Primary Completion: 2012-06
• Status Verified: 2013-11
• Study Completion: 2015-08
• Last Update Submitted: 2017-02-15
• Last Update Posted: 2017-02-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9000

Inclusion Criteria

• Chronic kidney disease

Exclusion Criteria

• excluded those patients who had ever been diagnosed with CKD before 1997

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Chronic kidney disease ICD-9	2012-Dec