ISRCTN74928896已完成3 期
A phase III randomised study to investigate the use of adoptive cellular therapy (ACT) in combination with conventional antiviral drug therapy for the treatment of cytomegalovirus reactivation episodes in patients following allogeneic haematopoietic stem cell transplant
Cell Medica Ltd (UK)0 个研究点目标入组 75 人开始时间: 2008年3月4日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 75
研究概览
简要总结
2014 results abstract in: http://www.bloodjournal.org/content/124/21/1109 [added 10/05/2019]
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Sibling T cell depleted allogeneic HSCT recipients where donor and recipient are both CMV seropositive
- •2. Aged 18 years or over
排除标准
- •1. Pregnant or lactating women
- •2. Co-existing medical problems that would place the patient at significant risk of death due to graft-versus-host disease (GVHD) or its sequelae
- •3. Human immunodeficiency virus (HIV) infection
- •To be assessed prior to CMV-specific T cell infusion (confirmed prior to product release):
- •4. Active acute GVHD greater than grade I
- •5. Concurrent use of systemic corticosteroids
- •6. Organ dysfunction as measured by:
- •6.1. Creatinine greater than 200 uM/l
- •6.2. Bilirubin greater than 50 uM/l
- •6.3. Alanine aminotransferase (ALT) greater than three times normal
研究者
相似试验
已完成
3 期
A phase III study to determine the role of a second autologous stem cell transplant as consolidation therapy in patients with relapsed multiple myeloma following prior high dose chemotherapy and autologous stem cell rescueRelapsed Multiple MyelomaMyelomaCancerISRCTN60123120The Leeds Teaching Hospitals NHS Trust (UK)293
已完成
3 期
The role of FluoroDeoxyGlucose-Positron Emission Tomography imaging in clinical stages Ia/IIa Hodgkin's diseaseCancerISRCTN99811594eukaemia Research Fund (UK)571
已完成
3 期
A randomised phase III clinical trial investigating the effect of Fragmin® added to standard therapy In patients with lung cancerCancerISRCTN80812769Velindre NHS Trust (UK)2,202
已完成
3 期
A phase III study to investigate a vaccine against COVID-19COVID-19 (SARS-CoV-2 infection)Infections and InfestationsISRCTN89951424niversity of Oxford10,300
已完成
3 期
Clinical trial to assess the importance of nephrectomyMetastatic renal cell carcinoma, clear cell carcinoma (the most common type of renal cell carcinoma).Malignant neoplasm of kidney, except renal pelvisCancerISRCTN19562321HS Greater Glagsow and Clyde (UK)450