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临床试验/NCT03863496
NCT03863496已完成不适用

Efficacy of Surgical Treatment by Different Pedicle Screw Systems in Pediatric Neuromuscular Spinal Deformity

Ilizarov Center2 个研究点 分布在 1 个国家目标入组 71 人开始时间: 2018年1月31日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
71
试验地点
2
主要终点
Second Scoliotic Curve

研究概览

简要总结

This study was sponsored by Federal state budgetary institution "Russian scientific center for traumatology and orthopedics" n.a. acad. G.A. Ilizarov" of the Ministry of Health of Russian Federation. The study will take place at this center.

It is expected to enroll 70 patients aged 6-25 years with NMD, all of whom will be subjected to thoracic and lumbar spinal deformity surgery.

Patients will be divided into two groups depending on skeletal maturity. The degree of skeletal maturity will be determined on the basis of an X-ray study of spinal and pelvic bones. The type of surgical correction will depend on the group.

详细描述

First group of patients: local dorsal access. Cranial access: at the level of posterior Th2 5 structures and caudally at the level of L4-S2 vertebrae with exposure of posterior upper spines of iliac wings. Skeletization of vertebrae will be done within transverse processes. Pedicle support points are set bilaterally cranially at each segment level for the space of 3 segments. Caudal support base is formed with pedicle screws in lateral masses of the sacral bone or iliac crests at the level of L5-S1 vertebrae. Control fluorography is performed in two standard planes in order to control screw position. Two "dynamic" rods are formed on the basis of the distance between screw heads allowing 2 cm for distraction; these are two rods connected with a longitudinal connector and bent following the normal sagittal spine profile. After that, channels are formed on both sides under m. erector spinae in the cranial/caudal direction. Pre-bent rods with connectors are placed into the prepared channels. The metal construct is stabilized with internal set screws. If necessary, the construct may be stiffened with crosslinks. Control fluorography is performed in two standard planes in order to control implant position and evaluate correction. The intervention completes with local dorsal spinal fusion with an autobone at the level of base screws. The wound is sewn up in layers tightly.

Group two: dorsal access to the posterior column is gained in accordance with the preoperative plan. The access length depends on the instrumentation area. Vertebral skeletization is performed within transverse processes. Subgroup 1 - pedicle support points are set bilaterally at each segment level. Subgroup 2 - pedicle support points are set bilaterally in every second segment. Segmented instrumentation of 3 cranial segments to prevent dislocation of metal construct elements at the level of Th2-4 or Th3-5 vertebrae is a special measure. Similar to group I, caudal support base is formed with pedicle screws in lateral masses of the sacral bone or iliac crests at the level of L5-S1 vertebrae. Control fluorography is performed after that in two standard planes in order to control screw position. Segmented facetectomy is recommended for additional spine mobilization. Pre-bent rods are placed into support points. Deformity correction is performed by means of a translational maneuver, segmented distraction (concave side) and compression (convex side). The metal construct is stabilized with internal set screws. If necessary, the construct may be stiffened with crosslinks. Control fluorography is performed in two standard planes in order to control implant position and evaluate correction. The intervention completes with dorsal spinal fusion with an autobone along the implants. The postoperative bed is subjected to Redon drain. The drainage is exteriorized to the skin via a separate puncture. The wound is sewn up in layers tightly.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
6 Years 至 25 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • Signed and dated informed consent for participation in the study (separate informed consents for child and parents/caregivers), obtained before conducting any study procedures
  • Verified and documented diagnosis (neuromuscular desease, NMD) with the results of neurologic examination
  • Deformity of thoracic and/or lumbar spine associated with NMD, which requires surgical intervention

排除标准

  • Patient unwillingness or inability to follow study procedures
  • Absence of signed and dated informed consent for participation in the study (as for child and for parents/caregivers)
  • Patient participation in another clinical study, which can influence the results of this study
  • Life expectancy <12 months
  • Concomitant diseases, which preclude patient participation in this study according to doctor's opinion

结局指标

主要结局

Second Scoliotic Curve

时间窗: before surgery

Second scoliotic curve before surgery in Cobb degrees

Kyphotic Curve Th5-Th12

时间窗: before surgery

Kyphotic curve Th5-Th12 before surgery in Cobb degrees

Tilt of the Pelvis Relative to the Horizon

时间窗: before surgery

tilt of the pelvis relative to the horizon before surgery in Cobb degrees

First Scoliotic Curve

时间窗: before surgery

First scoliotic curve before surgery in Cobb degrees

Lordotic Curve L1-S1

时间窗: before surgery

Lordotic curve L1-S1 before surgery in Cobb degrees

次要结局

  • Kyphotic Curve Th5-Th12(10 days after surgery)
  • Tilt of the Pelvis Relative to the Horizon(10 days after surgery)
  • Second Scoliotic Curve(10 days after surgery)
  • First Scoliosis Curve(10 days after surgery)
  • Lordotic Curve L1-S1(10 days after surgery)

研究者

发起方
Ilizarov Center
申办方类型
Other
责任方
Sponsor

研究点 (2)

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