A RANDOMIZED STUDY TO COMPARE THE EFFECT OF NEBULIZED ROPIVACAINE AND NEBULIZED ROPIVACAINE WITH DEXMEDETOMIDINE ON ATTENUATING HEMODYNAMIC RESPONSE TO INTUBATION IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANAESTHESIA
Overview
- Phase
- Phase 2/3
- Status
- Not yet recruiting
- Sponsor
- Ashu Agarwal
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- .To access and compare they hemodynamic changes HR , SBP, DBP,MAP, Spo2 and ETco2 in both the groups
Overview
Brief Summary
THIS STUDY IS TO COMAPRE THEY EFFECT OF NEBULIZED ROPIVACAINE AND NEBULIZED ROPIVACAINE WITH DEXMEDETOMIDINE ON THE HEMODYNAMICE RESPONSE TO INTUBATION IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANAESTHESIA. PREOPERATIVE VITALS ARE MOINTORED AND BEFORE INTUBATION PATIENTS IS NEBULIZED WITH ONE OF THEY GROPUS AND AFTER NEBULIZATION THEY VITALS ARE MONITORED AND THEY ARE VITALS ARE MOINTORED THROUGH OUT THEY PROCEDURE AT DIFFERENT TIME INTERVAL AND AFTER EXTUBATION PATIENTS IS ACCESED FOR SORE THROAT AND COUGH RESPOSNE . ALL THIS DATA WOULD BE ENTRED IN EXCEL SHEET AND FINAL RESULT WOULD BE CONCULUDED.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Double
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patient giving consent for study
- •Weight 40-70 kg
- •ASA grade 1 & 2
- •Patients undergoing surgery under general anaesthesia
- •All lab investigations within normal range.
Exclusion Criteria
- •Patient with a history of sore throat or upper respiratory tract infection
- •Hemodynamically unstable patients
- •Emergency patients
- •Patients with a history of allergy to local anesthetics
- •Patents with a history of allergy to dexmedetomidine
- •Patients with a history of cardiac, liver, or renal disorders.
- •Patient with a difficult airway where the anticipated duration of laryngoscopy exceeded 15 seconds.
- •ASA 3 and 4.
Outcomes
Primary Outcomes
.To access and compare they hemodynamic changes HR , SBP, DBP,MAP, Spo2 and ETco2 in both the groups
Time Frame: Before Nebulization ,After Nebulization, Before Intubation ,After Intubation, 5 minute after intubation ,at skin closure ,after extubation, 5 minutes after extubation
Secondary Outcomes
- 1. To compare the cough response at extubation in both the groups.(2. The incidence rate of postoperative sore throat. In both the groups.)
Investigators
Ashu Agarwal
Jhalawar medical college Jhalawar