Effects of Focal Muscle Vibration as a Countermeasure Against Hypoactivity-induced Neuromuscular Deconditioning
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Isometric force measurement
研究概览
简要总结
Muscle deconditioning, characterized by a loss of muscle mass and strength, is a frequent consequence of prolonged lower limb unloading. Beyond muscle mass loss, reduced neural drive contributes significantly to strength decline, highlighting the need for interventions targeting neuromuscular function during immobilization. Focal muscle vibration (FMV) has shown promise in modulating neuromuscular excitability by activating muscle spindle afferents and inducing cortical adaptations. Chronic use of FMV has been associated with significant strength gains and improved neural command. This makes FMV an effective rehabilitation tool. Its simplicity and non-invasiveness further make it a practical countermeasure.
详细描述
This study hypothesizes that a 10-day FMV protocol can induce neural adaptations to limit strength loss during unilateral lower limb suspension, offering a novel strategy against neuromuscular function decline.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women.
- •Aged 18 to 45 years.
- •Body Mass Index (BMI) between 18,5 and 24,9 kg/m².
- •Engaging in at least 1.5 hours per week of physical activity (e.g., brisk walking, running, swimming, cycling).
- •Provided informed consent after receiving detailed information about the study.
- •Affiliated with or beneficiaries of a social security system
排除标准
- •Chronic cardiovascular, neuromuscular, bone, metabolic, and/or inflammatory disorders.
- •Personal history and/or risk factors for thrombosis.
- •Use of antidepressant medications.
- •Use of neuroactive substances likely to alter corticospinal excitability (e.g., hypnotics, antiepileptics, psychotropics, muscle relaxants) during the study.
- •Recent bone or ligament trauma within the past 12 months.
- •Inability to perform the physical efforts required for the study.
- •Recent participation in a sporting competition or intense, unusual physical activity within the past month.
- •Corticosteroid treatment within the past 3 months.
- •Any skin lesions at the planned vibrator application site.
- •Simultaneous participation in another interventional medical study.
- •Pregnant or breastfeeding women.
- •Individuals unable to understand the purpose and conditions of the study or unable to provide informed consent.
- •Individuals deprived of liberty or under guardianship
研究组 & 干预措施
CONTROLE
the control group WILL not receive this countermeasure.
干预措施: NO Focal muscle vibration (Device)
VIBRATION
Participants will benefit a local vibration countermeasure program for the knee extensor muscles.
干预措施: Focal muscle vibration (Device)
结局指标
主要结局
Isometric force measurement
时间窗: Day 1, 7, 14, 28, 33
Maximal isometric force (% decrease) in knee extension of the immobilized leg will be evaluated
次要结局
- Determination of plasma molecular markers of bone and muscle remodeling(Day 1, 7, 14, 28, 33)
- Cortical activation of sensorimotor areas measurement(Day 1, 7, 14, 28, 33)
- Muscle volume measurement(Day 1, 7, 14, 28, 33)
- Maximum voluntary force measurement(Day 1, 7, 14, 28, 33)
- Jumping performance measurement(Day 1, 7, 14, 28, 33)
- Postural balance measurement(Day 1, 7, 14, 28, 33)
- Neuromuscular fatigue measurement(Day 1, 7, 14, 28, 33)
- Force-velocity-endurance measurement(Day 1, 7, 14, 28, 33)
- Voluntary activation level evaluation(Day 1, 7, 14, 28, 33)
- Cortico-spinal excitability measurement(Day 1, 7, 14, 28, 33)
- Spinal excitability evaluation(Day 1, 7,14 , 28, 33)
- Plasma molecular markers of thrombotic risk evaluation(Day 1, 7, 14, 28, 33)