Effects of AV Port Reversal in Citrate CVVH - The CIRE Study (CItrate REcirculation Study)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- change in clearance after AV port reversal
研究概览
简要总结
The aim of this study is to determine the effects of AV port reversal (AVPR) on recirculation, clearance, post-filter ionized calcium and subsequently citrate dosing.
详细描述
Rationale:
AV port reversal (AVPR) has been demonstrated to increase recirculation in venous catheters used in ICU for CVVH. The effects of this frequently used manoeuvre have not been described in the setting of CVVH using regional citrate anticoagulation.
Objective:
The aim of this study is to determine the effects of AVPR on recirculation, clearance, post-filter ionized calcium and subsequently citrate dosing.
Study design and methods:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Critically ill patients requiring CRRT for AKI (RIFLE criteria)
- •Written informed consent from the patient or legal representative
- •No AV port reversal had taken place before inclusion in the study
- •Diuresis is minimal or the patient is anuric so that effects of changes in clearance as a consequence of diuresis are minimalized and do not influence study outcomes.
- •The patient has undergone CVVH for a number of days, ensuring good metabolic control, so that possible short term loss of clearance as a consequence of AV port reversal has no detrimental effects.
排除标准
- •pre-existing chronic renal insufficiency requiring dialysis
- •chronic immunosuppression
- •liver cirrhosis Child-Pugh C
- •severe or shock-related hepatitis
- •Pregnancy
研究组 & 干预措施
AV port reversal
Patients undergoing citrate CVVH.
干预措施: AV port reversal (Other)
结局指标
主要结局
change in clearance after AV port reversal
时间窗: 8 hours
change in citrate concentration in circuit after AV port reversal
时间窗: 8 hours
change in post-filter ionised Ca after AV port reversal
时间窗: 8 hours
次要结局
未报告次要终点
研究者
Willem Boer
MD
Ziekenhuis Oost-Limburg