Norwegian COgnitive Impairment After STroke (NorCOAST) Study

Completed

• Conditions: Dementia; Mild Cognitive Impairment; Stroke

• Registration Number: NCT02650531
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke

Detailed Description

About 15000 Norwegians suffer a stroke every year and 2/3 will be more or less disabled. In addition to motor impairments and comorbidities, disability after stroke is often related to post stroke dementia (PSD) or mild neurocognitive disorder (NCD). However, these problems are hardly addressed in stroke or dementia research and frequently ignored in clinical practise. In the Nor-COAST study an interdisciplinary research group will collaborate to establish a research platform across all Norwegian Health Authorities. The overall aim of the study is to improve competence on PSD and NCD in order to improve individual health outcomes following a stroke. The specific objectives are to determine the incidence of PSD and NCD and the consequences on function and use of health care services and to enhance the early detection of PSD and NCD by identifying a set of risk factors, ranging from genetics to physical activity. The incidence and impact of PSD and NCD on function and use of health care services, medication and life-style changes are important when planning future health care services. Tools identifying patients at risk might improve diagnostic work up and together with knowledge on pathogenic aspects it will contribute to future treatment and prevention of PSD and NCD.

Study Timeline

• Study Start: 2015-05
• Study First Submitted: 2015-12-10
• Study First Submitted QC: 2016-01-07
• Study First Posted: 2016-01-08
• Primary Completion: 2018-10-08
• Study Completion: 2018-10-08
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-06
• Last Update Posted: 2022-02-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 816

Inclusion Criteria

• Stroke diagnosis according to the WHO criteria

Exclusion Criteria

• Not scandinavian speaking

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Score on the Montreal cognitive assessment (MOCA)	18 months	Performance based test

Secondary Outcome Measures

Name	Time	Method
Brain Imaging	18 months	MRI
Selfreported habits concerning smoking, alcohol, diet and medication using standardised questionnaires	18 months
Score on the Montreal cognitive assessment (MOCA)	3 months	Performance based test
Score on Short Physical Performance Battery (sppb)	18 months	Physical function by performance based tests
Time spent in upright position	18 months	measured by bodyworn sensors

Trial Locations

Locations (1)

Norwegian University of Science and Technology; 🇳🇴 Trondheim, Norway