Comparison of Immediate Therapeutic Effects of 3% Diquafosol and 2% Rebamipide in Dry Eye Disease

Korea University Anam Hospital1 个研究点分布在 1 个国家目标入组 30 人开始时间: 2022年10月3日最近更新: 2025年12月22日

干预措施

试验速览

阶段: 4 期
状态: 已完成
发起方: Korea University Anam Hospital
入组人数: 30
试验地点: 1
主要终点: visual analog scale (VAS) score

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study compares the immediate therapeutic and mucin-secreting effects 30 minutes after instillation of 3% diquafosol and 2% rebamipide in dry eye disease.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Single Group
主要目的: Treatment
盲法: Double (Participant, Outcomes Assessor)

入排标准

年龄范围: 19 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•patients 19 years or older
•complaint of at least one dry eye symmptom and tear breakup time < 7 seconds

排除标准

•Sjogren's syndrome
•prescription history of systemic steroids or immunosuppressants
•prior ocular surgery within six months of enrollment
•treatment with diquafosol or rebamipide eye drops within 2 weeks of enrollment
•treatment with punctal plug within 1 month of enrollment
•intraocular pressure exceeding 25mmHg
•usage of contact lens during the study
•active ocular infection
•pregnancy or breast-feeding

研究组 & 干预措施

R) DQS, L) REB

Other

This is a paired-eye design study. Patients were randomly assigned to receive 3% diquafosol in the right eye and 2% rebamipide in the contralateral left eye, with the treatment assignment blinded to the examiner and patients.

干预措施: 3% diquafosol (right eye) and 2% rebamipide (left eye) (Drug)

R) REB, L) DQS

Other

This is a paired-eye design study. Patients were randomly assigned to receive 3% diquafosol in the left eye and 2% rebamipide in the contralateral right eye, with the treatment assignment blinded to the examiner and patients.

干预措施: 2% rebamipide (right eye) and 3% diquafosol (left eye) (Drug)