CTRI/2018/04/013343已完成不适用
A Randomized Controlled Trial comparing the effect of Letrozole and Clomiphene Citrate on endometrial development in infertile women with Polycystic Ovarian Disease
AIIMS Academics and Research department Jodhpur1 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2018年4月20日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To Compare the endometrial thickness during ovulation induction using Letrozole and clomiphene citrate in infertile women with PCOS
研究概览
简要总结
Randomisation followed by
Ovulation induction from day 2 to day 6 of cycle
then TVS will be done from day 11 to day 18
Injection hCG 5000 IU given when follicle size reach > 18 mm
Ovulation will be confirmed by transvaginal sonography
Pregnancy- assessed by hCG measurement after missed periods
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)（—）
- 性别
- Female
入选标准
- •Polycystic ovarian syndrome having infertility for at least 1 year.
排除标准
- •1.Hypothyroidism 2.Hyperprolactinemia 3.Male factor infertility 4.Tubal infertility 5.Females using other medications known to affect reproductive functions ( oral contraceptive pills, GnRH agonists and antagonists, anti-androgens) 6.Medical morbidities ( poorly controlled type 1 or type 2 DM; undiagnosed liver disease; history of deep vein thrombosis; pulmonary embolus; cerebrovascular accident; uncontrolled hypertension; suspected cervical carcinoma, endometrial carcinoma or breast carcinoma.
结局指标
主要结局
To Compare the endometrial thickness during ovulation induction using Letrozole and clomiphene citrate in infertile women with PCOS
时间窗: Day 11 to day 18 of cycle
次要结局
- 1. To Compare the ovulation rate(2. To compare the pregnancy rate)
研究者
研究点 (1)
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