Repletion of Ergothioneine in Patients With Kidney Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- plasma levels of ergothioneine
研究概览
简要总结
Dialysis removes potentially harmful chemicals from the blood but can also remove potentially valuable chemicals. One potentially valuable chemical called ergothioneine, which comes from the diet, is low in the blood of people receiving dialysis. For this research study, the investigators hope to learn how well a daily ergothioneine supplement will replenish the levels in the blood of people with kidney failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •kidney failure receiving hemodialysis or peritoneal dialysis
排除标准
- •blood transfusion within 90 days
- •taking supplements which contain ergothioneine
研究组 & 干预措施
Ergothioneine
Ergothioneine (range 5 mg to 25 mg) oral daily for up to 16 weeks
干预措施: Ergothioneine (Dietary Supplement)
结局指标
主要结局
plasma levels of ergothioneine
时间窗: weeks 1, 2, 4, 8, 12, and 16 (while taking ergothioneine); and weeks 20 and 24 (after stopping ergothioneine)
ergothioneine levels will be measured in plasma
erythrocyte levels of ergothioneine
时间窗: weeks 1, 2, 4, 8, 12, and 16 (while taking ergothioneine); and weeks 20 and 24 (after stopping ergothioneine)
ergothioneine levels will be measured in whole blood
次要结局
未报告次要终点
研究者
Tammy Lisa Sirich
Assistant Professor of Medicine
Stanford University