Repletion of Ergothioneine in Patients With Kidney Failure

Not Applicable

Not yet recruiting

• Conditions: Esrd

• Registration Number: NCT06487546
• Lead Sponsor: Stanford University

Brief Summary

Dialysis removes potentially harmful chemicals from the blood but can also remove potentially valuable chemicals. One potentially valuable chemical called ergothioneine, which comes from our diet, is low in the blood of people receiving dialysis. For this research study, we hope to learn how well a daily ergothioneine supplement will replenish the levels in the blood of people with kidney failure.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-06
• Study First Submitted: 2024-06-27
• Study First Submitted QC: 2024-06-27
• Last Update Submitted: 2024-06-27
• Study First Posted: 2024-07-05
• Last Update Posted: 2024-07-05
• Study Start: 2024-10-01
• Primary Completion: 2027-04-01
• Study Completion: 2027-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• kidney failure receiving hemodialysis or peritoneal dialysis

Exclusion Criteria

• blood transfusion within 90 days
• taking supplements which contain ergothioneine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
plasma levels of ergothioneine	weeks 1, 2, 4, 8, 12, and 16 (while taking ergothioneine); and weeks 20 and 24 (after stopping ergothioneine)	ergothioneine levels will be measured in plasma
erythrocyte levels of ergothioneine	weeks 1, 2, 4, 8, 12, and 16 (while taking ergothioneine); and weeks 20 and 24 (after stopping ergothioneine)	ergothioneine levels will be measured in whole blood