A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill

Not Applicable

Completed

• Conditions: Keratitis
• Interventions: Other: Hydrogel dressing; Other: Lacrilube ointment

• Registration Number: NCT00513734
• Lead Sponsor: Barts & The London NHS Trust

Brief Summary

Corneal damage in critically ill patients is common. There are currently two popular methods of treatment in the UK; hydrogel dressings and lubricating ointment. We propose to randomise patients to have a different treatment for each eye and see which one is more effective.

Detailed Description

Microbial keratitis, particularly pseudomonas-related, has been widely reported amongst Intensive therapy unit (ITU) patients and the need for effective eye care in ITU has been recognised for some time. We compare two popular methods of eye care; a hydrogel dressing and lacrilube ointment. Each recruited patient had each eye randomised to different treatments. Daily ophthalmology ward rounds were undertaken to identify any corneal exposure keratopathy. Patients were removed from the trial if one eye developed significant exposure needing treatment.

Study Timeline

• Study Start: 2004-09
• Study Completion: 2005-02
• Status Verified: 2007-08
• Study First Submitted: 2007-08-08
• Study First Submitted QC: 2007-08-08
• Last Update Submitted: 2007-08-08
• Study First Posted: 2007-08-09
• Last Update Posted: 2007-08-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• All patients admitted to Intensive care and expected to stay for more than 2 days

Exclusion Criteria

• Primary orbital injury

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Hydrogel dressing	Geliperm Hydrogel Dressing
2	Lacrilube ointment	Lacrilube ointment

Primary Outcome Measures

Name	Time	Method
Development of clinically significant corneal exposure	throughout length of admission to ITU