Doppler Sonography of Cerebral Blood Flow for Early Prognostication After Out-of-hospital Cardiac Arrest

Completed

• Conditions: Cardiac Arrest

• Registration Number: NCT03270683
• Lead Sponsor: Rennes University Hospital

Brief Summary

Objective: To assess neurologic prognostication by early Transcranial Doppler Sonography (TCD) in comatose survivors after cardiac arrest.

Design: Prospective study between May 2016 and November 2017 in a medical intensive care unit and cardiac intensive care unit in a university hospital.

Patients: all comatose patients older than 18 years successfully resuscitated from an out-of-hospital cardiac arrest (OHCA). Patients for whom OHCA is associated with traumatic brain injury, no window for TCD measurements, or dead before neurological prognostication are excluded.

Detailed Description

The investigators measure the pulsatility index (PI) and diastolic flow velocity (DFV) of the right and left middle cerebral artery during the first 12 h after return of spontaneous circulation (ROSC). The highest value of DFV and the lowest of PI will use for the statistical analysis. Cerebral Performance Category evaluate neurologic outcome at hospital discharge.

Data provided by early TCD after ROSC are associated with neurological outcome. The use of these data could lead to the development of therapeutics improving cerebral perfusion in patient resuscitated from an OHCA.

Study Timeline

• Study Start: 2016-05-02
• Study First Submitted: 2017-08-29
• Study First Submitted QC: 2017-08-31
• Study First Posted: 2017-09-01
• Primary Completion: 2017-10
• Study Completion: 2017-10
• Status Verified: 2019-12
• Last Update Submitted: 2019-12-26
• Last Update Posted: 2019-12-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• older 18 years
• out-of-hospital cardiac arrest with recovery of spontaneous cardiac activity

Exclusion Criteria

• transcranial doppler not done or not interpretable
• associated cranial trauma
• died without neurological assessment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluate the relation between TCD measurements and neurologic outcome at hospital discharge	6 months	Good score = CPC 1-2 and bad score = CPC 3-5

Secondary Outcome Measures

Name	Time	Method
Measurement of pulsatility index	12 hours	Evaluate the association between pulsatility index and period of cardiac arrest
Entry of doppler parameters	6 months	Identify a doppler parameter than can improve the neurological outcome

Trial Locations

Locations (1)

CHU Rennes; 🇫🇷 Rennes, France