Evaluation of the Effects of Anterior Clinoid Process Pneumatization on Optic Canal Morphometry and Retinal Nerve Fiber Layer Thickness Using Computed Tomography and Optical Coherence Tomography: A Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Optic Canal Length
研究概览
简要总结
This retrospective cohort study aims to evaluate the potential effects of anterior clinoid process (ACP) pneumatization on optic canal morphometry and retinal nerve fiber layer (RNFL) thickness. ACP pneumatization is an anatomical variation that may alter the morphology of the optic canal and potentially influence the optic nerve.
Patients aged 18-65 years with available head and neck computed tomography (CT) imaging and optical coherence tomography (OCT) examinations between August 2018 and July 2025 will be retrospectively reviewed. Optic canal length and diameter will be measured using CT images, and RNFL thickness parameters will be obtained from OCT records. Measurements will be compared between patients with and without ACP pneumatization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 to 65 years.
- •Availability of head and neck computed tomography (CT) imaging in the hospital archive.
- •Availability of optical coherence tomography (OCT) examination records in the hospital archive.
- •CT and OCT examinations performed between August 2018 and July 2025.
排除标准
- •Age <18 years or >65 years. History or evidence of diabetes mellitus. History or evidence of hypertension. Glaucoma. Any condition or diagnosis that may cause optic nerve pathology (e.g., optic neuritis, compressive optic neuropathy, optic atrophy, demyelinating disease affecting the optic nerve).
- •Inadequate image quality or incomplete CT/OCT data preventing reliable measurements.
研究组 & 干预措施
ACP Pneumatization Absent
Participants without radiological evidence of anterior clinoid process (ACP) pneumatization on computed tomography imaging.
ACP Pneumatization Present
Participants with radiologically confirmed anterior clinoid process (ACP) pneumatization identified on computed tomography imaging.
结局指标
主要结局
Optic Canal Length
时间窗: Baseline (retrospective review of CT images obtained between August 2018 and July 2025)
Optic canal length measured on computed tomography (CT) images.
Optic Canal Mean Diameter
时间窗: Baseline (retrospective review of CT images obtained between August 2018 and July 2025)
Optic canal mean diameter measured on computed tomography (CT) images.
Retinal Nerve Fiber Layer (RNFL) Thickness
时间窗: Baseline (retrospective review of OCT images obtained between August 2018 and July 2025)
Peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography (OCT).
次要结局
未报告次要终点
研究者
Sinem Keser
Principal Investigator
Elazıg Fethi Sekin Sehir Hastanesi