ISRCTN46806801
已完成
未知
Discovery of novel biomarkers in peripheral arterial disease/metabolic syndrome
niversity of Dundee (UK)0 个研究点目标入组 80 人2007年6月19日
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- Type 2 diabetes and peripheral arterial disease
- 发起方
- niversity of Dundee (UK)
- 入组人数
- 80
- 状态
- 已完成
- 最后更新
- 8年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •For Phase 1 study subjects with PAD and type 2 diabetes will be included. PAD will be defined as patients with classical symptoms of intermittent claudication plus an Ankle brachial Blood Pressure Index (ABPI) of \<0\.9, the accepted cut off level for such a diagnosis.
- •For Phase 2 study patients with short distance claudication (\<200 yards) will be selected for the walking study, as their walking distances are more reproducible (i.e. using the standardized Gardner walking treadmill protocol no more than 25% variation from 2 consecutive treadmill tests performed at least a week apart during the screening period). Patients for this second study will be type 2 diabetic patients not receiving insulin.
排除标准
- •1\. Contraindication to thiazolidinedione group of drugs
- •2\. Subjects taking sulphonylureas
- •3\. Subjects with cardiovascular disease event within last three months (such as Myocardial Infarction \[MI], unstable angina and stroke)
- •4\. For Phase 2 study, subjects having more than 25% variation from 2 consecutive treadmill tests performed at least a week apart
结局指标
主要结局
未指定
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